DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	527	Identity:	123/527 - (23%)
Similarity:	229/527 - (43%)	Gaps:	55/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTI----ISFTPSHRCSRPEDYQPNSTS 61
            |:::...:..|..|.||:.|..|..   ::..|:..::.|    :..|||:.....| ..||.:.
Human     1 MEVEEAFQAVGEMGIYQMYLCFLLA---VLLQLYVATEAILIALVGATPSYHWDLAE-LLPNQSH 61

  Fly    62 --------------LLSCSVMQFDKEFKCTSWDFERESNYESITTELEWVCDDAYKLAVGQSFFF 112
                          ||:.:..:..|....:       |::.||.:|...:.:.:||::...||||
Human    62 GNQSAGEDQAFGDWLLTANGSEIHKHVHFS-------SSFTSIASEWFLIANRSYKVSAASSFFF 119

  Fly   113 IGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFF----TSFVGSLPWFSFTRFISGLFMDTQY 173
            .|..:|.|.||.|:||.||...    .|||.:.|..    ..|..|..:|:.|||:.|:......
Human   120 SGVFVGVISFGQLSDRFGRKKV----YLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMS 180

  Fly   174 VLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLFPVF 238
            ::.::|:.|.:...:.... ..|.|:|:.||:.....:..::.:||......:|....:.|..:|
Human   181 LVAFVLLNECVGTAYWALA-GSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLF 244

  Fly   239 LHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDSVFDEFIKHYREKLNNSQNKS---SDTFMGM 300
            :.||..||.::|:..:||::|..:||.| |::..:.          .|.:..|:|   :.:|:.:
Human   245 IPESPRWLYSQGRLSEAEEALYLIAKRN-RKLKCTF----------SLTHPANRSCRETGSFLDL 298

  Fly   301 LRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCYLPA-GLTIILFQNK-I 363
            .|...|...|:||:....:.::.:..|:.:...:|.|.:...:.||...:|: .|.|.|...| .
Human   299 FRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWF 363

  Fly   364 GRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVS-LGRYGAVVAYDAEAQYAAEIIPT 427
            |||....|.|.:|.:......:|....|...::|:....:| ||:.....|::....|.:|:.||
Human   364 GRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPT 428

  Fly   428 SVKGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLMISFILLIGACLCLALPETLHKNLPQNL 492
            .::..|:....:........:.:|..|......||.::.....|....|.|.|||||:..|.:..
Human   429 VIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETF 493

  Fly   493 EEGEMFA 499
            .:.::::
Human   494 SDLQVYS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	122/506 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	93/381 (24%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	90/373 (24%)
		MFS_1	111..450	CDD:284993	86/354 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850