DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and slc22a2

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	586	Identity:	141/586 - (24%)
Similarity:	250/586 - (42%)	Gaps:	90/586 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRP-------------EDY 55
            :.:||:.|.||..||.:...|...:|..|..|.......|||.|.|..|             :|.
Zfish     5 EEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWSLQDA 69

  Fly    56 QPNSTSLLS---------CSVMQFDKEFKCT--------------------------SWDFERES 85
            :..:..|::         |.  :||.::..|                          .|:::...
Zfish    70 RRATVPLINGSSGASYSQCG--RFDVDWNATGLSCENPDGDFNQSQLSVMPMMSCVDGWEYDYVG 132

  Fly    86 NYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTS 150
            . :|..||.:.||.||:.:.:.|:...||..:|||..|||||:.||:.:.:::       :||..
Zfish   133 R-QSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMT-------NFFIG 189

  Fly   151 FVGSLPWFS-------FTRFISGLFMDTQYVLMYILVFEYLSPQH-RTFGLNIILGVFYCVGLMI 207
            ..|.|...|       ..|.:.|..:...:::.|:|:.|.:...| ||.|:...|  |:.:|:::
Zfish   190 VTGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQL--FFSMGILL 252

  Fly   208 SPWIAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDD 272
            .|.:|.::||||......::|.:..|.:..|:.||..||||:.|..:|.:..:.:||.|.:.:..
Zfish   253 LPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTLSK 317

  Fly   273 SVFDEFIKHYREKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGIS 337
            .:  |.:|.     :|..:.|:.:||.:.:|.:||.:|.||........:.:..|...:..:|.:
Zfish   318 KI--ETLKD-----DNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGGN 375

  Fly   338 PFKLFSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFM 402
            .:..|..||...|||...|:|...:|||:     ..|..|.|.|....|:....|.....|...:
Zfish   376 VYVDFLISGIVELPAAFLILLTIERIGRR-----LPFATANIVAGAACLITAFIPDSMFWLKSAV 435

  Fly   403 VSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIY-LGTFYKPLPSLMI 466
            ..:||.|..:|::.......|:.||.::..||:....:.:.....:.:::| |...:..||.::.
Zfish   436 ACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIF 500

  Fly   467 SFILLIGACLCLALPETLHKNLPQNLEEGEMFAKGEKWYFFPCFSRRPKTQKSATQLESSDGITN 531
            ..:..:...|.|.||||....||:.:::.|...:.::         .|:..:....|.:||...|
Zfish   501 GALAFVAGGLVLLLPETKGVPLPETIDDIEHPNRNKE---------NPQQSQQLENLMTSDVTKN 556

  Fly   532 K 532
            |
Zfish   557 K 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	131/535 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	96/380 (25%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	132/536 (25%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	99/389 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950