DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and slc22a4

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	561	Identity:	138/561 - (24%)
Similarity:	227/561 - (40%)	Gaps:	108/561 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DLQSVLEKCGNFGPYQI---LLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPE---------- 53
            |...:....|.:||:|:   |.|.:....|....|:.   ..:..||:|.|..||
Zfish     3 DYDDITSFLGTWGPFQLTVFLALAISILPNGFVGLYI---VFVGDTPAHECLIPEQINISSVWRD 64

  Fly    54 -------------------------------DYQPNSTSLLSCSVMQFDKEFKCTSWDFERESNY 87
                                           :|.||    :..::.|.:.|.....|.:.:|...
Zfish    65 AAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPN----VEVNLSQIETEPCVDGWSYSQEFYQ 125

  Fly    88 ESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPA----CVLSTLTGASGDFF 148
            .:|.||.:.||:..||..:..|.:|.|..:|:...|.::||.||.|.    ..|.|:|    ...
Zfish   126 STIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTIT----ILI 186

  Fly   149 TSFVGSLPWFSFTRFISGLFMDTQYVLMYILVFEYLSPQHRT-FGLNIILGVFY--CVGLMISPW 210
            ..|..|...||...|..|....:.||:.|:|..|.|||..|. ||   .||||.  .:|.|..|.
Zfish   187 QMFSPSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFG---SLGVFMGSGIGQMFFPL 248

  Fly   211 IAIWVTNWRNYLWAASLPAL-GMLLFPV--FLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDD 272
            .|.::.:||   |.....|| |:|.||:  |:.||..|||::|:..:||..||..|:.|.....:
Zfish   249 AAYFIRSWR---WLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPE 310

  Fly   273 SVFDEFIKHYREKLNNSQNKSSDTFMGMLRTPRLRKFTII-----------LLIKS---MIITIA 323
            .:|..      .::..:..|            |::|.:|:           :||.|   |:||::
Zfish   311 VIFSS------SEIEEAAKK------------RIQKHSILDILSNCNAVSTILICSLLWMVITMS 357

  Fly   324 FDILSRNVEGVGISPFKLFSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVA 388
            :..|..|...:..:|:..|..|....:||.:...|......|:....::|.:|..:     ..:.
Zfish   358 YYALILNTTNLHGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGAL-----IFII 417

  Fly   389 TLDPSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIY 453
            .|.|::...|...:..||:.....|:.......:|:.||.|:...:.:..:.....:..|.:|||
Zfish   418 QLIPTELQGLATALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIY 482

  Fly   454 LGTFYKPLPSLMISFILLIGACLCLALPETLHKNLPQNLEE 494
            ||.:|:.:|.::|..:.|....:.|.|||:..|.||:.:.:
Zfish   483 LGNYYRYIPYIVIGGLALFSGVMSLLLPESKGKVLPETIAQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	136/546 (25%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	103/395 (26%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	137/547 (25%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	103/398 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950