DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	567	Identity:	135/567 - (23%)
Similarity:	235/567 - (41%)	Gaps:	76/567 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDYQPNSTSL--- 62
            |....:|:..|..|.:|::...|......:.:.|.|.|...:..|.|.|..|.:|...:|::
Mouse     1 MAFTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEPTTNVSGV 65

  Fly    63 ---LSCSVMQFDKEFKC--------------------------TSWDFERESNYESITTELEWVC 98
               .:..:.|......|                          ..|.::|.....:|..|.:.||
Mouse    66 WLRAAIPLNQHGDPEPCRRYVEPQWALLKPNASSHGVATEGCKDGWVYDRSIFPSTIVMEWDLVC 130

  Fly    99 DDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPWFSFTRF 163
            :......:.||.:..|..:|:..||.||||:||....|.|.|..|.....|::|||...:...||
Mouse   131 EARTLRDLAQSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGAATAYVGSFSAYCVFRF 195

  Fly   164 ISGLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLP 228
            :.|:......:....||.|::..:.||.. .|:||..:.:|.:|...:|..:..||...:|.|.|
Mouse   196 LMGMTFSGIILNSLSLVVEWMPTRGRTVA-GILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSAP 259

  Fly   229 ALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQ----------VDDSVFDEFIKHYR 283
            .|...|:..:|.||:.|||..||.::|.::|:.||..|||:          |...:.|||
Mouse   260 FLVFFLYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGERLTTEVVSSYIQDEF----- 319

  Fly   284 EKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFC 348
                 :..::|::.:.:.|||.:|:.|..|:......::|:..|:.:::..|:|.:.:.:..|..
Mouse   320 -----ASVRTSNSILDLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGII 379

  Fly   349 YLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVA 413
            .:||.|........:||:....:.|.:..::..|..::     |.|...|.....:||:.....:
Mouse   380 DIPAMLVATTTMIYVGRRATVSSFLILAGLMVIANMFM-----PEDLQTLRTVQAALGKGCLASS 439

  Fly   414 YDAEAQYAAEIIPTSVK--GRGVANIHV-VGNAFAFFSSYIIYLGTFYKPLPSLMISF---ILLI 472
            :.....:..|:.||.::  |.|.|:::. :|...|   ..|..||.....||.  :||   .:|.
Mouse   440 FICVYLFTGELYPTEIRQMGMGFASVNARLGGLVA---PLITTLGEISPVLPP--VSFGATSVLA 499

  Fly   473 GACLCLALPETLHKNLPQNLEEGEMFAKGEKWYFFPCFSRRPKTQKS 519
            |..:...|.||.:..|.:.:...|...|..:       |:|...|||
Mouse   500 GMAVACFLTETRNVPLVETIAAMERRVKQGR-------SKRDTEQKS 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	126/526 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	100/387 (26%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	126/527 (24%)
		MFS	138..507	CDD:119392	101/389 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950