DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and CG8654

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001246441.1	Gene:	CG8654 / 37275	FlyBaseID:	FBgn0034479	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	130/536 - (24%)
Similarity:	215/536 - (40%)	Gaps:	98/536 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLEKCGNFGPYQ-----ILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDYQPNSTSLLSC 65
            ::.:.|:|..||     |:||..||     :..|......::......|.......|.|.   .|
  Fly    24 IISQIGDFRRYQLFFFFIVLLCKFG-----TGWHTLGHIFLAAPTPLSCKTENVTDPCSD---EC 80

  Fly    66 SVMQFDKE-FKCTSWDFERESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRI 129
            |..:||.. |:.|            |.||....|:.....::.||...:|...|||.||..|||.
  Fly    81 SETEFDTSVFQST------------IITEWNLTCESKQLASLSQSIVMLGILFGSILFGMFADRY 133

  Fly   130 GRLPA----CVLSTLTGASGDFFTSFVGSLPWF-SFTRFISGLFMDTQYVLMYILVFEYLSPQHR 189
            ||.||    |.:..:||     ....|....|| ...||:..:.........::|:.|.:.|:.|
  Fly   134 GRRPAFLTCCFMQLITG-----LIVCVSPYYWFYCLFRFLVAVATAGTMTTSFVLLMEIVGPKKR 193

  Fly   190 TFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEK 254
            .. :.|:..:.:.:|.......|.::..||.:.::.::.::..:::...:.||..||.|.||.:|
  Fly   194 EM-VAILYQIPFNIGHASLALFAYFIREWRWFQFSITIFSIVFVIYIWLVPESPRWLFTTGKLDK 257

  Fly   255 AEKSLRGVAKFNGRQVDDSVFDEFIKHYREKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMI 319
            :.|.|..:||.| :...:::..|....| ..|...|.....|.:.:.|||.:|..||.:....::
  Fly   258 SIKILEKIAKCN-KAPTETIRPEIEAAY-GALAARQPVKKGTVVDLFRTPYMRIKTIFMANNWLV 320

  Fly   320 ITIAF-------DILSRNV-------EGVGISPFKLFSYSGFC-------YLPAGLTIILFQ--N 361
            :.:.:       ..|..|:       .||||        .|.|       ||....|::|..  :
  Fly   321 VCMVYYGTAQYVSALGGNIFISNAIAAGVGI--------PGTCLCALMTKYLGRKKTLLLSNGCS 377

  Fly   362 KIGRKGMACASLFVGAI-ITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAEII 425
            .:|...:||.|....|: :|.||                     :|.:||.:.:.....|..|:.
  Fly   378 ALGLILLACLSTQAEAVRVTCAT---------------------IGLFGASITFPNVYLYGGELF 421

  Fly   426 PTSVKGRGVANIHVVGNAFAFFSSYIIYL---GTFYKPLPSLMISFILLIGACLCLALPETLHKN 487
            ||.|:..||....:||...:..:..|:.|   |.:..||...:.|.:.::|.   :.||||....
  Fly   422 PTVVRSSGVGLCSMVGRIGSIVAPLIVDLAAYGLWVAPLIFGIFSILAMLGT---IFLPETRGTP 483

  Fly   488 LPQNLEEGEMFAKGEK 503
            ||:.||:||.|.:.:|
  Fly   484 LPETLEDGETFGRKKK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	123/516 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	94/403 (23%)
CG8654	NP_001246441.1	SP	85..487	CDD:273317	109/453 (24%)
CG8654	NP_001246441.1	MFS	87..477	CDD:119392	101/441 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	3	3.010