DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	128/572 - (22%)
Similarity:	232/572 - (40%)	Gaps:	96/572 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQIL----LLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDYQPNSTS 61
            |....:|::.|..|.:|:|    |:....:....:.|..||..:    |.|||..|  ...||||
  Rat     1 MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAV----PHHRCWVP--LLDNSTS 59

  Fly    62 ------------LLSCSV-----------MQF--------DKEFKCTSWD------------FER 83
                        ||:.|:           ::|        :.....|:|.            ::.
  Rat    60 QASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWVYDH 124

  Fly    84 ESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFF 148
            .:...:|.|..:.|||......:.||.|..|..:|:...|:.:||.||......|.|..:.....
  Rat   125 STFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTI 189

  Fly   149 TSFVGSLPWFSFTRF-----ISGLFMDTQYVLMY--------------------ILVFEYLSPQH 188
            .:.:.:.|.:...||     ::|:.|:|..:.|:                    :.|.|:.|.|.
  Rat   190 AALMPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSLLLAVMEWTSAQA 254

  Fly   189 RTFGLNI-ILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKF 252
            ....:.: .||  :..|.:::..:|..|.:||....|.|.|.....::..:|.|||.||:|.|:.
  Rat   255 GPLMMTLNALG--FSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGRL 317

  Fly   253 EKAEKSLRGVAKFNGRQVD-DSVFDEFIKHYREKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIK 316
            :::.:.|:.||..|.|:.: |::..|.::...::..|. |::......:|.||.||..|.|
  Rat   318 DQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNG-NQAGARLGTLLHTPGLRLRTFI---- 377

  Fly   317 SMIITIAFDI----LSRNVEGVGISPFKLFSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGA 377
            ||:...||..    |:.:::.:|.:.|.|.:..|...||..:..:|..:::||:....:||.:..
  Rat   378 SMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQASSLVLPG 442

  Fly   378 IITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGN 442
            :...|.     .|.|.:..:|...:..||......|:.....:::|:.||.::...|....|...
  Rat   443 LCILAN-----ILVPREMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLGQVAAR 502

  Fly   443 AFAFFSSYIIYLGTFYKPLPSLMISFILLIGACLCLALPETLHKNLPQNLEE 494
            ..|.....:..||.:...||.|:...:.::.....|.||||.:..||..:::
  Rat   503 GGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQD 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	125/556 (22%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	91/402 (23%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	97/443 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346843
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950