DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	125/565 - (22%)
Similarity:	238/565 - (42%)	Gaps:	46/565 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPE------------ 53
            |....:|::.|..|.:|::.:.:.....::.:.|...|...:..|.|.|..|.
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65

  Fly    54 ----DYQPNSTSLLSCSVMQFDKEF-------------KC-TSWDFERESNYESITTELEWVCDD 100
                |.|....|.|..:..|:...|             .| ..|.::..:...:|.||...||..
  Rat    66 WLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSH 130

  Fly   101 AYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPWFSFTRFIS 165
            .....:.||.:.:|..||::.|||||||:||....:|:.|..|......::..:...:...|.:|
  Rat   131 RAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLS 195

  Fly   166 GLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPAL 230
            |:.:.:..:....|..|:: |.|....:..::|..|.:|..:...||..|.:||:.....|:|..
  Rat   196 GMSLASIAINCMTLNVEWM-PIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFF 259

  Fly   231 GMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDSVFDEFIKHYREKLNN--SQNKS 293
            ...::..|..|||.|..:.|:.:...::|:.||:.||:|.:.:...  |:..|..|..  :.:|.
  Rat   260 IAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLS--IEVLRTSLQKELTLSKG 322

  Fly   294 SDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCYLPAGLTIIL 358
            ..:.|.:||.|.||...:.|.:.....:.|:..|..:::|.|:|.:.:....|...|||.....|
  Rat   323 QASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFL 387

  Fly   359 FQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAE 423
            ..|.:||:....|||.:..|.....|.:     |..::::...:..||:.....:::....|..|
  Rat   388 VINSMGRRPAQMASLLLAGICILVNGII-----PKSHTIIRTSLAVLGKGCLASSFNCIFLYTGE 447

  Fly   424 IIPTSVKGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLMISFILLIGACLCLALPETLHKNL 488
            :.||.::..|:.....:....:..|..:.....||..:|..:...:.::.:.:...|||||.:.|
  Rat   448 LYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPL 512

  Fly   489 PQNLEEGEMFAKGEKWYFFPCFSRRPKTQKSATQLESSDGITNKL 533
            |..:::.:..::|::      ..::.:.||....|::|....|.|
  Rat   513 PDTVQDLKSRSRGKQ------NQQQQEQQKQMMPLQASTQEKNGL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	115/510 (23%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	86/373 (23%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	116/511 (23%)
		MFS	135..505	CDD:119392	87/377 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		6/42 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950