DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	567	Identity:	145/567 - (25%)
Similarity:	253/567 - (44%)	Gaps:	73/567 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSH-------------RC--------- 49
            |.|.|.||.:|..:..|...|.:..:..:.....:...|.:             ||
  Rat     8 LRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEEEWN 72

  Fly    50 -SRPEDYQP-----------------NSTSLLSCS-VMQFDKE----FKCTSWDFERESNYESIT 91
             :.||.:.|                 |::|.|||. :..|...    ..| |.|:.....:.:|.
  Rat    73 LTTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPC-SGDWRYVETHSTIV 136

  Fly    92 TELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTL-TGASGDFFTSFVGSL 155
            ::.:.||.:|:.|.:.|:...:|...|:...||.|||.|||...::|.. .|.:| ...:|..:.
  Rat   137 SQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVGITG-VVVAFAPNF 200

  Fly   156 PWFSFTRFISGLFMDTQYVLMYILVFEYL-SPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWR 219
            ..|...||:.|:|....::..:::|.|.: |.|.|..|  |::.:|:.:|::|.|.||.:..:|:
  Rat   201 SVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVG--IVIQMFFTLGIIILPGIAYFTPSWQ 263

  Fly   220 NYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDSVFDEFIKHYRE 284
            ....|.|||:...||:...:.||..||:|:.:.|||.:.||.|||.||:.:.        .:|.|
  Rat   264 GIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLS--------SNYSE 320

  Fly   285 KLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCY 349
            .....:..|:.:.:.::|||::||.|:||:.......:.:..|...:..:|.:.:..|..||...
  Rat   321 ITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVE 385

  Fly   350 LPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAY 414
            ||..|.|:|...::||:....||..|..:....|.:|     |.....|...:.:|||.|..:|:
  Rat   386 LPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFL-----PEGIPWLRTTVATLGRLGITMAF 445

  Fly   415 DAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIY-LGTFYKPLPSLMISFILLIGAC--L 476
            :......:|:.||:::..||:....:.:.....:.:::: |...:..||  :|.|.:|...|  |
  Rat   446 EIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELP--LIIFGILASVCGGL 508

  Fly   477 CLALPETLHKNLPQNLEEGEMFAKGEKWYFFPCFSRRPKTQKSATQL 523
            .:.||||....||:.:|:.|.....:   ...| .|:.|||.|.:.:
  Rat   509 VMLLPETKGIALPETVEDVEKLGSSQ---LHQC-GRKKKTQVSTSNV 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	134/528 (25%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	102/376 (27%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	135/529 (26%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	105/385 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347437
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950