DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	136/578 - (23%)
Similarity:	238/578 - (41%)	Gaps:	98/578 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDY---------- 55
            |....:|:..|..|.:|::...|......:.:.|.|.|...:..|.|.|..|.:|
  Rat     1 MAFTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEATTNDSGA 65

  Fly    56 ----------------------------QPNSTS----LLSCSVMQFDKEFKCTSWDFERESNYE 88
                                        :||::|    ...|.          ..|.::|.....
  Rat    66 WLRATIPLNQHGVPEPCQRYTEPQWALLEPNTSSHGVATEGCK----------DGWVYDRSIFPS 120

  Fly    89 SITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVG 153
            :|..|.:.||:......:.||.:..|..:|:..||.||||:||....|.|.|..|.....|::||
  Rat   121 TIVMEWDLVCEARTLRDLAQSIYMSGVLVGAALFGSLADRLGRKAPLVWSYLQLAVSGAVTAYVG 185

  Fly   154 SLPWFSFTRFISGLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNW 218
            |...:...||:.|:......:....||.|::..:.||.. .|:||..:.:|.:|...:|..:..|
  Rat   186 SFSAYCIFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVA-GILLGFSFTLGQLILAGVAYLIRPW 249

  Fly   219 RNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVD-DSVFDEFIKHY 282
            |...:|.|.|.|...|:..:|.||:.|||..||.::|.::||.||..|||:.: :.:..|.:..|
  Rat   250 RWLQFAVSAPFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLRKVAMMNGRKAEGERLTIEVVSSY 314

  Fly   283 REKLNN--SQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYS 345
               :.|  :..::|::.:.:.|||.:||.|..|::.....::|:..|:.:::..|:|.:.:.:..
  Rat   315 ---IQNEFASVRTSNSILDLFRTPGIRKVTCCLMMVWFSNSVAYYGLAMDLQKFGLSIYLVQALF 376

  Fly   346 GFCYLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLGRYGA 410
            |...:||.|........:||:....:.|.:..::..|..::     |.|...|.....:||:...
  Rat   377 GIIDIPAMLVATTTMIYVGRRATVSSFLVLAGLMVIANMFV-----PEDLQTLRTVQAALGKGCL 436

  Fly   411 VVAYDAEAQYAAEIIPTSVK--GRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLMISF---IL 470
            ..::.....:..|:.||.::  |.|.|:::......|  :..|..||.....||.  :||   .:
  Rat   437 ASSFICVYLFTGELYPTEIRQMGMGFASVNARLGGLA--APLITTLGEISPVLPP--VSFGATSV 497

  Fly   471 LIGACLCLALPETLHKNLP---------QNLEEGEMFAKGEKWYFFPCFSRRPKTQKS 519
            |.|..:...|.||  :|:|         ..::||.              |:|...||:
  Rat   498 LAGMAVICFLTET--RNVPLVETIAAMESRVKEGH--------------SKRDTEQKN 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	128/537 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	100/379 (26%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	108/427 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940