DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	144/584 - (24%)
Similarity:	244/584 - (41%)	Gaps:	94/584 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LQSVLEKCGNFGPYQ---ILLLGLFGYTNIVSSLH--YFSQTIISFTPSHRCSRP---------- 52
            :..|||:.|.||.:|   .|||.|     |.:||.  |.....:.|||.|.|..|
  Rat     4 VDDVLEQVGEFGWFQKQAFLLLCL-----ISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCG 63

  Fly    53 ----EDYQ-------PNSTSLLSCSVMQFDKEFK-----CT--------------------SWDF 81
                |:..       |:..:......|:::.::.     |.                    .|.:
  Rat    64 WSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVY 128

  Fly    82 ERESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGD 146
            :...:  ||.||...||.||:|:.:.||...:|..|||:..||:|||.||....:::||..:...
  Rat   129 DTPGS--SIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSG 191

  Fly   147 FFTSFVGSLPWFSFTRFISGLFMDTQYVLMYILVFEYL-SPQHRTFGLNIILGVFYCVGLMISPW 210
            ..|:...........|.:.|:.....:|..|.|:.|:: |...||..  |:..:.:.|||:....
  Rat   192 VLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTA--ILYQMAFTVGLVGLAG 254

  Fly   211 IAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDSVF 275
            :|..:.:||....|.|||....||:..|:.||..|||::.:..:|.:.:..:|:.||:.....:
  Rat   255 VAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADL- 318

  Fly   276 DEFIKHYREKL----NNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGI 336
                     |:    .::..|.|.:|..:.|||.|||.|:||:.......:.:..|..:|...|.
  Rat   319 ---------KMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGA 374

  Fly   337 SPFKLFSYSGFCYLPAGLTIILFQNKIGR-KGMACASLFVGAIITAATGYLVATLDPSDYSVLLG 400
            :.:..|.||.....||...|::..::||| ..:|.::|..||      ..|:....|.:...|..
  Rat   375 NLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGA------ACLLMIFIPHELHWLNV 433

  Fly   401 FMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIY-LGTFYKPLPSL 464
            .:..|||.||.:.........||:.||.::..|:.....:.:....|:.:::: |...::.||.:
  Rat   434 TLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLI 498

  Fly   465 MISFILLIGACLCLALPETLHKNLPQNLEEGEMFAKGEKWYFFPCFSRRPKTQKSATQLESSDG 528
            :...:.|....:.|.||||....||:.:||.|...:           |:.|.:::...|:...|
  Rat   499 LFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR-----------RKSKAKENTIYLQVQTG 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	133/536 (25%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	95/378 (25%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	134/537 (25%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	106/409 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950