DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	560	Identity:	130/560 - (23%)
Similarity:	241/560 - (43%)	Gaps:	92/560 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRC---SRPEDYQPNSTS- 61
            |..|.:|...|:.|.:|||.:......|:::..|...:...:....|||   ....|...|:.|
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSG 65

  Fly    62 ------LLSCSV---------------------MQFDKEFK---------C-TSWDFERESNYES 89
                  ||..|:                     :||:..|.         | ..|.:::.:...:
Mouse    66 ILSQDDLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMDGWVYDQRTFLST 130

  Fly    90 ITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGR--------LPACVLSTLTGASGD 146
            ..||...||......:|.:..|.||...|....|:|:|:.||        |...:..|.|..:..
Mouse   131 TVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAITGTCTALAPT 195

  Fly   147 FFTSFVGSLPWFSFTRFISGLF---MDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMIS 208
            ||.        :...||::||.   ::|..||   |:.|:.||:.:.....:.:...:..||:::
Mouse   196 FFI--------YCLLRFLTGLCIIPINTNSVL---LMLEWTSPKTQALVTTLSMSSHHFGGLILA 249

  Fly   209 PWIAIWVTNWRNYLWAASLPALGMLLFPV--FLHESAEWLLTKGKFEKAEKSLRGVAKFNG-RQV 270
             .:|....||.:...|.|:| :.:||.|.  :|.|||.||:...|.:||.:.||.||..|| :..
Mouse   250 -GLAFAFQNWHHLQLAISVP-IFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVASKNGIKNS 312

  Fly   271 DDSVFDEFIKH-YREKLNNSQNKSSDTFMGMLRTPRLRK-FTIILLIKSMII--TIAFDILSRNV 331
            :|.:..|.::. .::::...:.|.|  ...:...|.||| ..::.|::.:.|  |:..::..:::
Mouse   313 EDVLTMEVVRTIMKDEIAIPRTKPS--LRDLFHMPNLRKRLCLLCLLRFLQISPTVGINMNLQHL 375

  Fly   332 EGVGISPFKLFSYSGFCYLPAGLTIILFQNKIGRK---GMACA--SLFVGAIITAATGYLVATLD 391
            :|   :.|...|.:....:||........|.|||:   .:.|.  .:|:.:|::.
Mouse   376 KG---NVFLTQSLTSAFSIPATALGGFLLNYIGRRISQLLPCLLFGIFLLSIVSV---------- 427

  Fly   392 PSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIYLGT 456
            |.:...||..:::|....:.:.|::...|::|::||.::...:..|.:.|...|..|..|:.|..
Mouse   428 PQEMQTLLVVLITLAGGSSAMIYNSNVLYSSELMPTVIRATALGVIGICGGVGAALSPLIMILTL 492

  Fly   457 FYKPLPSLMISFILLIGACLCLALPETLHKNLPQNLEEGE 496
            :...||.::...:.::|..|.|.||||.::.||.::::.|
Mouse   493 YSASLPWIIYGVLSILGGLLPLILPETKNQPLPDSIQDVE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	125/542 (23%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	94/394 (24%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	98/424 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030