DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	138/556 - (24%)
Similarity:	239/556 - (42%)	Gaps:	67/556 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRC---------------- 49
            |..|.:|.:.|:.|.:|||.:......||:.|.|...:...:..|:|||
  Rat     1 MAFQDLLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNG 65

  Fly    50 -----------------SRPED----YQP-------NSTSLLSCSVMQFDKEFKCTSWDFERESN 86
                             .|||.    .||       |.|   ..||.:.|.|.....|.:::.:.
  Rat    66 NLSQDDLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGT---FSSVTEPDTEPCVDGWVYDQSTF 127

  Fly    87 YESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSF 151
            ..:|.||.:.||:.....::.:..|..|..:|:|.:|.|.||.||....:.::|..|..:...:|
  Rat   128 LSTIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAF 192

  Fly   152 VGSLPWFSFTRFISGLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYC---VGLMISPWIAI 213
            ..:...:...||::|:...|......:|:.|:..|:.:.....::|    |   :|..:...:|.
  Rat   193 APTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLL----CAGAIGQTVLAGLAF 253

  Fly   214 WVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNG-RQVDDSVFDE 277
            .|.||.:...|.|:|...:|:...:|.|||.||:...|.:|..|.|..||..|| :...|.:..|
  Rat   254 TVRNWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIE 318

  Fly   278 FIKH-YREKLNNSQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKL 341
            .::. .:|:|..||.|||  ...:.|||.|||...:|.:...::.::...|..|.:.:.|:.|.|
  Rat   319 VVRTIMKEELEASQTKSS--LWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQHLRINVFLL 381

  Fly   342 FSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLG 406
            ....|...:||.|..|...|.:||:   .:.||:  |.......|.....|.:..:|...:.:.|
  Rat   382 QCLLGIITIPANLVGIFLVNHLGRR---ISQLFI--ISLFGISILAIIFVPQEMQILRMVLATFG 441

  Fly   407 RYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLMISFILL 471
            ...:.|:..:...:|.|::||.::...:..|.:.|:..|..|...:.|.|:...||.::...:..
  Rat   442 GVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYSDSLPWIIYGVLSF 506

  Fly   472 IGACLCLALPETLHKNLPQNLE----EGEMFAKGEK 503
            :|..:.|.||||.::.||.:::    ||....:|::
  Rat   507 LGGLVVLLLPETKNQPLPDSIQDVENEGRASRQGKQ 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	131/527 (25%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	96/376 (26%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	131/527 (25%)
		Aldolase_II	39..>85	CDD:294146	4/45 (9%)
		MFS	125..506	CDD:119392	99/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347358
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940