Protein Alignment CG17751 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_650816.3
• Gene: CG17751 / 42336
• FlyBaseID: FBgn0038717
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 136/570 - (23%)
• Similarity: 221/570 - (38%)
• Gaps: 92/570 - (16%)

  Fly     1 MDLQSVLEKCGNFGPYQIL----LLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDYQPNST- 60
            |....:|:..|..|.:|:|    |:....:....|.|..||..:    |||||..|  ...|||
Human     1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAV----PSHRCWAP--LLDNSTA 59

  Fly    61 -----------SLLSCSV-------------------MQFDKEFKCTSWD------------FER 83
                       :||:.|:                   ...|.....|||.            ::|
Human    60 QASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDR 124

  Fly    84 ESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFF 148
            .....:|..:...|||......:.||.:..|..:|:...|..:||.||......|.|..|.....
Human   125 SIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTA 189

  Fly   149 TSFVGSLPWFSFTRF-----ISGLFMDTQYV--------------------LMYILVFEYLSPQH 188
            .:|..:.|.:...||     ::|:.|:|..:                    |..:.|.|:.:.:.
Human   190 AAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAARA 254

  Fly   189 RTFGLNI-ILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLFPVFLHESAEWLLTKGKF 252
            |...:.: .||..:..||..:  :|..|.:|.......|:|.....|:..:|.|||.||||.|:.
Human   255 RPLVMTLNSLGFSFGHGLTAA--VAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRL 317

  Fly   253 EKAEKSLRGVAKFNGR-QVDDSVFDE-FIKHYREKLNNSQNKSSDTFMG-MLRTPRLRKFTIILL 314
            :...:.|..||..||: .|.|::..| .:...||:|:..|..:|   :| :||.|.||..|.|..
Human   318 DWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPAS---LGTLLRMPGLRFRTCIST 379

  Fly   315 IKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGAII 379
            :........|..|:.:::.:|.:.|.|..:.|...:||.:..:|..:.:||:....|||.:..:.
Human   380 LCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLC 444

  Fly   380 TAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAF 444
            ..|.     ||.|.:...|...:..||..|...|:.....|::|:.||.::...|....:.....
Human   445 ILAN-----TLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGG 504

  Fly   445 AFFSSYIIYLGTFYKPLPSLMISFILLIGACLCLALPETLHKNLPQNLEE 494
            |.....:..||.....||.|:...:.::.....|.||||....||..:::
Human   505 AILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQD 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	133/554 (24%)
		MFS	109..481	CDD:119392	97/400 (24%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	134/555 (24%)
		MFS	122..541	CDD:119392	103/428 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950