DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17751 and slc22a2

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	147/566 - (25%)
Similarity:	247/566 - (43%)	Gaps:	77/566 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRC---SRPE---------DYQ-P 57
            :||..|.|..:|..:..|..:.::|.|..|.....:.|.|.:||   ..||         :|. |
Frog     7 LLEHIGEFDAFQKQIFILLCFISVVFSPIYVGIVFLGFVPDYRCVSAGIPEPSNECEWTLNYTGP 71

  Fly    58 NST--SLLSCSVMQFDKEFKCTS----------------------WDFERESNYESITTELEWVC 98
            |.:  ||......|:|.::..||                      ||:....:  |:.||...||
Frog    72 NGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITNCKDGWDYNTTGS--SLVTEFNLVC 134

  Fly    99 DDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTL-TGASGDFFTSFVGSLPWFSFTR 162
            .|::||...||...||..:|.:..||:|||.||.|..:.|.| ||..| ...:|..:.|.....|
Frog   135 GDSWKLDFFQSCVNIGFFIGGLISGYIADRFGRKPFLISSILITGIFG-ILMAFAPNYPLVVTFR 198

  Fly   163 FISGLFMDTQYVLMYILVFEYLSPQH-RTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAAS 226
            ||.|......::..||||.|::..:| ||.|  |:....:.|||::...:|..:.:||......:
Frog   199 FIQGFVSKGCWLSGYILVAEFVGLEHRRTVG--IVYQAAFTVGLLLLSGVAYVLPHWRWLQMTVT 261

  Fly   227 LPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNGRQVDDSVFDEFIKHYREKLNNSQ- 290
            :|....|.:...:.||..||:::.:..:|:..:..:||.||:.|.|         :.|.|...:
Frog   262 IPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVPD---------FLESLTADEE 317

  Fly   291 --NKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFCYLPAG 353
              .|...:|:.::|||::||.|:||:.......:.:.....::.....:.:..|..|.....|:.
Frog   318 AGEKQVPSFLDLVRTPQIRKHTLILMYIWFTCAVVYQGSIMHMGSTAENIYFDFFISALVEFPSA 382

  Fly   354 LTIILFQNKIGRK--GMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSLGRYGAVVAYDA 416
            :.||:..:::||:  .:.|      .|||..| .|:....|..||.|:..:..:.|.|..|:|:.
Frog   383 ILIIVTVDRVGRRYPWLVC------CIITGIT-CLITAFIPHGYSWLIITLSCVSRMGITVSYEM 440

  Fly   417 EAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIY-LGTFYKPLPSLMISFILLIGACLCLAL 480
            .....||:.||.::..|:.....:.:.....:.:|:| |...::.||.::.:.:..:...|...|
Frog   441 VCLVNAELYPTFIRNLGIMVCSSMCDLGGVITPFIVYRLAAIWQELPLIVFAVLATVSGILVYFL 505

  Fly   481 PETLHKNLPQNLEEGEMFAKGEKWYFFPCFSRRPKTQKSATQLESS 526
            |||..:.||:.:||.|...|..|           .|:.:.|.||.|
Frog   506 PETKGRALPETIEEAENLHKQVK-----------TTKLATTYLEVS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	134/523 (26%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	96/379 (25%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	135/524 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000