DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17751 and slc22a6

DIOPT Version :9

Sequence 1:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	136/558 - (24%)
Similarity:	232/558 - (41%)	Gaps:	83/558 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLQSVLEKCGNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTPSHRCSRPEDYQPNSTS---L 62
            |..|.:||..|..|.||::.:.|......:.:.|...|...:..|.|||.....::..:.:   |
Frog     1 MAFQEILESIGGMGRYQVIHVVLLSLPVFMLASHNLMQNFTAAIPRHRCQINGSFEETNFTGPWL 65

  Fly    63 LSCSVMQFDKEF-KC----------------------------TSWDFERESNYESITTELEWVC 98
            .:...|:...|| ||                            ..|.::......:|.|:.:.||
Frog    66 RALVPMKPTGEFSKCLRYTTPQYHLLMDNFTQNVDELETETCVDGWVYDHSEFASTIITQWDLVC 130

  Fly    99 DDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTL----TGASGDFFTSFVGSLPWFS 159
            :......|.||.:..|..:||:.||.|:|:.||.|..:.|.|    ||....|..:::    |:.
Frog   131 NHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQMSVTGICAAFSPNYI----WYC 191

  Fly   160 FTRFISGLFMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWA 224
            ..||::|..:....:..|.|:.|::...:|.| .:...|..|.:|.::...:|..:.:|.....|
Frog   192 IFRFLTGTALSGIVLNSYSLIVEWIPTGNRAF-TSTATGYCYTMGQLVLVGLAFMIRDWHWLQLA 255

  Fly   225 ASLPALGMLLFPVFLHESAEWLLTKGKFEKAEKSLRGVAKFNG-RQVDDSVFDEFIKHYREKLNN 288
            ||||.....|:..::.||..||:..||.|.|.|:|:.|||.|| ::..:.:..|.:|...::..:
Frog   256 ASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGEKLTVEVLKSSMQREIS 320

  Fly   289 SQNKSSDTFMGMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGIS-------------PFK 340
            :...|:.:.:.::|||.:|:.:..:.......:.|:..|:.:::..|:|             |.|
Frog   321 ASKHSTYSVLDLVRTPVVRRISFCISCTWFSTSFAYYGLALDLQSFGVSIYIIQIIFGTVDIPAK 385

  Fly   341 LFSYSGFCYLPAGLTIILFQNKIGRKGMACASLFVGAIITAATGYLVATLDPSDYSVLLGFMVSL 405
            .|||....|             |||:.:...:|     |.|....||....|.||..:...|...
Frog   386 FFSYFVMTY-------------IGRRVLQALTL-----ILAGIAILVNICVPQDYQTVRTSMAVF 432

  Fly   406 GRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVVGNAFAFFSSYIIYL----GTFYKPLPSLMI 466
            |:.....:::....|..|:.||.::..|:.    :|...|.....|..|    |..|..||.::.
Frog   433 GKGCLAASFNCLFLYTGELYPTVIRQSGMG----LGTMMARLGGIIAPLAQMTGDIYHSLPLIIF 493

  Fly   467 SFI-LLIGACLCLALPETLHKNLPQNLEEGEMFAKGEK 503
            ..: :|.|...|. |||||...||:.:|:.|...|.:|
Frog   494 GCLPILSGIAGCF-LPETLGVPLPETIEDVESSDKKQK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	127/533 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	97/394 (25%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	104/433 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100