Protein Alignment CG7342 and SV2A

DIOPT Version :10

• Sequence 1: NP_650815.2
• Gene: CG7342 / 42335
• FlyBaseID: FBgn0038716
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_055664.3
• Gene: SV2A / 9900
• HGNCID: 20566
• Length: 742
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 115/580 - (19%)
• Similarity: 201/580 - (34%)
• Gaps: 201/580 - (34%)

  Fly    88 MGYQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVA----NLIAMTG 148
            :|:....:|.|...:|:.|..|| .:.::|.:||:.:.|.|||.:||...|:::    ::.|...
Human   186 VGFVLPSAEKDMCLSDSNKGMLG-LIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFS 249

  Fly   149 NLLTIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLS-ICIGFFYCLGSM--- 209
            :.:..:.|  .|||  |::||:....:..:::....|::....|...|| :|:  |:.:|.:
Human   250 SFVQGYGT--FLFC--RLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM--FWMIGGVYAA 308

  Fly   210 AAPWI-------------AVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVC 261
            |..|.             |....|||.|:|..:.|.:.........|||.::.:...|:|.|.:.
Human   309 AMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMV 373

  Fly   262 LKRVAKINGR-----------------HVEESAYAEFIE-ECKCSQQNQKASPHLLDL------- 301
            ||:|...|.|                 |.|:    |.|| :.......|:.....|.|
Human   374 LKQVHDTNMRAKGHPERVFSVTHIKTIHQED----ELIEIQSDTGTWYQRWGVRALSLGGQVWGN 434

  Fly   302 FQT---PRLRRHTLIL----------------FFKSMV--------------------------I 321
            |.:   |..||.||::                :|..|:                          .
Human   435 FLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNF 499

  Fly   322 TL--------------------------------CY--DAVSRN--------------------- 331
            ||                                ||  |..|.|
Human   500 TLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEY 564

  Fly   332 ----------------------VQGLGISPFVMFSLS---ATAILPACLLIIALQDRIGRKAMAS 371
                                  |.|.|...::::.:|   ..|:||..::...|.|:|||..|.:
Human   565 KFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLA 629

  Fly   372 ASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVA-YNSGAQYATELIPTCVRGQG 435
            .|.::|.:       ..|..|..:..:.::..|.:.|  ||::| :|:......||.|:..|...
Human   630 GSSVMSCV-------SCFFLSFGNSESAMIALLCLFG--GVSIASWNALDVLTVELYPSDKRTTA 685

  Fly   436 VAAVH-----VAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLLLPETLHRTL 490
            ...::     .|....:.|::::..|::.    |.:.......||:.|.|.||||..:.|
Human   686 FGFLNALCKLAAVLGISIFTSFVGITKAA----PILFASAALALGSSLALKLPETRGQVL 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_650815.2	2A0119	12..491	CDD:273328	115/580 (20%)
SV2A	NP_055664.3	synapt_SV2	1..742	CDD:130366	115/580 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..144