DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and SV2B

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001309960.1	Gene:	SV2B / 9899	HGNCID:	16874	Length:	683	Species:	Homo sapiens

Alignment Length:	662	Identity:	130/662 - (19%)
Similarity:	215/662 - (32%)	Gaps:	247/662 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCL 67
            :.:.|:::|| ..|.|.|   ||.|:.:  ||               .|||    :|..|.|..|
Human    94 QYETIMDECG-HGRFQWI---LFFVLGL--AL---------------MADG----VEVFVVSFAL 133

  Fly    68 PLNRNISTPNTCYSYNYELYMGYQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVV 132
            |                         .:|.|...:.:.|..||. :.::|.:.|:.:||.|||.:
Human   134 P-------------------------SAEKDMCLSSSKKGMLGM-IVYLGMMAGAFILGGLADKL 172

  Fly   133 GRLPILIVANLIAMTGNLLTIWS----TNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRT 193
            ||..:|.::  :|:..:..::.|    ....|||  |:||||.......:::....|::....|.
Human   173 GRKRVLSMS--LAVNASFASLSSFVQGYGAFLFC--RLISGIGIGGALPIVFAYFSEFLSREKRG 233

  Fly   194 LGLSICIGFFYCLGSM---AAPWIAV-------------LMRSWRGFLLTTSLPLLVVPFFYLIV 242
            ..|| .:|.|:..|.:   |..|..:             ...|||.|::..:||..|.......:
Human   234 EHLS-WLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFM 297

  Fly   243 PESIQWLISKQKYDSAVVCLKRVAKIN--GRHVEESAYA-----------EFIE----------- 283
            |||.::|:...|:|.|.:.||:|...|  .:...|..:.           ||||
Human   298 PESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQR 362

  Fly   284 -----------------ECKCSQQNQKA--------------------SPHLLDLFQTPRLRRHT 311
                             .|.........                    .|.::..||....:...
Human   363 WLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKM 427

  Fly   312 LILF-------------------------------------FKSMVITLCY-------DAVSRNV 332
            .:.|                                     |:......||       |...:|.
Human   428 KVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNC 492

  Fly   333 -------------------------------QGLGI-----SPFVMFSLS---ATAILPACLLII 358
                                           :|..:     :.|:::.:|   :.::||..::..
Human   493 TIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISA 557

  Fly   359 ALQDRIGRKAMASASLLLSGI--FISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQ 421
            .|.|||||..|...|:|:|.:  |....|.   :.||......|....|:       .|:|:...
Human   558 LLMDRIGRLKMIGGSMLISAVCCFFLFFGN---SESAMIGWQCLFCGTSI-------AAWNALDV 612

  Fly   422 YATELIPTCVRGQGVAAVH-------VAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLL-GACL 478
            ...||.||..|......::       :.|.  |.|::::..|:.|     .|:|...||: |..:
Human   613 ITVELYPTNQRATAFGILNGLCKFGAILGN--TIFASFVGITKVV-----PILLAAASLVGGGLI 670

  Fly   479 CLLLPETLHRTL 490
            .|.||||..:.|
Human   671 ALRLPETREQVL 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	128/653 (20%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	41/169 (24%)
SV2B	NP_001309960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
SV2B	NP_001309960.1	Sugar_tr	8..683	CDD:331684	130/662 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910