DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	524	Identity:	143/524 - (27%)
Similarity:	235/524 - (44%)	Gaps:	47/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KILEKCGDFSRLQM--IMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCLP 68
            :||::.|.....|.  :.:|...::|:  |.|...|...:..|.:.|.....||....|    ||
Human     5 EILDRVGSMGHFQFLHVAILGLPILNM--ANHNLLQIFTAATPVHHCRPPHNASTGPWV----LP 63

  Fly    69 LNRN---------ISTPNTCYSYNYELYM-----GY------QSFPSEMDWVCADAWKLTLGQSM 113
            :..|         :..||.....:.:..|     |:      .|..:|.|.||.......:.||:
Human    64 MGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSI 128

  Fly   114 FFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGIATDSNFVM 178
            |..|.::|.:|||.|:|..||.|||..:.|:.........:|....::.:||.:.|.......:.
Human   129 FMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLS 193

  Fly   179 MYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLVVPFFYLI-- 241
            ..||.:|::...:|.: :|..:|:.|..|....|.:|..:..||...||.|:|..|   |:|.
Human   194 TVILNVEWVPTRMRAI-MSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFV---FFLSSW 254

  Fly   242 -VPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEECKCSQQNQ----KASPHLLDL 301
             .||||:||:...|...|:..|:|||..||:..|....:  :||.|.:.|.:    ||.....||
Human   255 WTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLS--LEELKLNLQKEISLAKAKYTASDL 317

  Fly   302 FQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAILPACLLIIALQDRIGR 366
            |:.|.|||.|..|..........|.:::..|:..|::.:::..:.....:||..:.|.....:||
Human   318 FRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGR 382

  Fly   367 KAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQYATELIPTCV 431
            ....:|:|||:|      |.|:..........|:...|:|.|:..::.:::....|.:||.||.:
Human   383 HTTQAAALLLAG------GAILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVI 441

  Fly   432 RGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLLLPETLHRTLPTSLED 496
            |..|:...::.....:..|..:..|..|...:|.||.|:.:|||....|.|||||::.||.::||
Human   442 RQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIED 506

  Fly   497 GENF 500
            .||:
Human   507 LENW 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	135/507 (27%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	43/152 (28%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	137/509 (27%)
		MFS	96..493	CDD:119392	112/408 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950