DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	140/525 - (26%)
Similarity:	233/525 - (44%)	Gaps:	45/525 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCLPLN 70
            :||::.|.....|.:.:.|..:..:..|.|...|...:..|.:.|.....|||...|    |||:
  Rat     5 EILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASIGPWV----LPLD 65

  Fly    71 RNISTPNTCYSYNYELYMGYQSFPS------------------------EMDWVCADAWKLTLGQ 111
            .| ..|..|..:   :::...|.|:                        |.|.||:......:.|
  Rat    66 PN-GKPEKCLRF---VHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCSSNKLKEMAQ 126

  Fly   112 SMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGIATDSNF 176
            |:|..|.:||..|:|.|:|..||.|||..:.|:.........:|.::.::.:||.:.|.:.....
  Rat   127 SIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGIS 191

  Fly   177 VMMYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLVVPFFYLI 241
            :...||.:|::..|:|.:. |..||:.|.:|......:|..:..||...||:|.|..:.......
  Rat   192 LSTVILNVEWVPTSMRAIS-STSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFFIFSLLSWW 255

  Fly   242 VPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEECKCSQQ----NQKASPHLLDLF 302
            |||||:||:...||..|:..|:|||..||:  :|......|||.|.:.|    :.|....|.|||
  Rat   256 VPESIRWLVLSGKYSKALKTLQRVATFNGK--KEEGKKLTIEELKFNLQKDITSAKVKYGLSDLF 318

  Fly   303 QTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAILPACLLIIALQDRIGRK 367
            :...|||.|..|..........|.:::..|:..|::.:::..:.....:||..:.|.....:||:
  Rat   319 RVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRR 383

  Fly   368 AMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQYATELIPTCVR 432
            ...|..|||:|      |.|:.......:...|..:|:|.|:..::.:::....|.:||.||.:|
  Rat   384 ITQSFLLLLAG------GAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLR 442

  Fly   433 GQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLLLPETLHRTLPTSLEDG 497
            ..|:...:|.....:..:..:..|..:...:|.:|.|..:|||......|.|||:|.||.::||.
  Rat   443 QTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIEDI 507

  Fly   498 ENFGK 502
            :|:.|
  Rat   508 QNWHK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	132/506 (26%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	42/173 (24%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	134/508 (26%)
		MFS	124..492	CDD:119392	103/376 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950