DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus

Alignment Length:	475	Identity:	113/475 - (23%)
Similarity:	211/475 - (44%)	Gaps:	62/475 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DSSCLPLNRNISTPNTCYSYNYELYMG-YQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLG 126
            ||:|           .|::::|.:..| .|:..|:.|.||.:.||:.:.:....||.:.|.::.|
Mouse   190 DSNC-----------DCHAWDYGIRTGLIQNVVSKWDLVCDNTWKVHIAKFSLLVGLIFGYLITG 243

  Fly   127 YLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSV 191
            .:||.|||.|:|:.:.:..:...|....|.|||:|...|...|.......:.:|.|.:|...|..
Mouse   244 CIADWVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGK 308

  Fly   192 RTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYD 256
            |.: :::...|....|....|.:|.|.|.|:........|.|::..::.|.|||::||::.|:::
Mouse   309 RFI-ITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFE 372

  Fly   257 SAVVCLKRVAKINGRHVEESAYAEFIE-ECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMV 320
            ||...:..:.:.|....|........| |.:.|::.:|..  ::.:..|..|.::.::|...|:.
Mouse   373 SAKKLILYLTQKNCVSPESDIKGVMPELEKELSRRPKKVC--IVKVVGTRNLWKNIVVLCVNSLT 435

  Fly   321 ITLCYDAVSRNVQGLGISP----------FVMFSLSATAILPACLLIIALQDRIGRKA------- 368
            ....:...:|::.|..:..          :.|.|::..:.|..||::..|    ||:.
Mouse   436 GYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIALASCLAMCLVVKFL----GRRGGLLLFMI 496

  Fly   369 -MASASLLLSGIFISVTG--------------GIIFAASASDKTTTLLVSLSVVGRFGVTVAYNS 418
             .|.||||..|: :::.|              .:..:.|..||.:   ::.|:||.|......:.
Mouse   497 LTALASLLQLGL-LNLIGKYSQHPDSELQLKLAVGMSDSVKDKFS---IAFSIVGMFASHAVGSL 557

  Fly   419 GAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYIL---FTRSVFSPLPEIILGVLSLLGACLCL 480
            ...:..|:.||.:|..|:..| :|...|...:|.|:   ..:..|  |..||....:|:.....|
Mouse   558 SVFFCAEITPTVIRCGGLGLV-LASAGFGMLTAPIIELHNQKGYF--LHHIIFACCTLICIICIL 619

  Fly   481 LLPETLHRTLPTSLEDGENF 500
            ||||:.::.||.::.:||::
Mouse   620 LLPESRNQNLPENIANGEHY 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	109/464 (23%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	40/149 (27%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		2A0119	98..631	CDD:273328	110/465 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188
		MFS	230..>359	CDD:119392	34/129 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.030