DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and SLC22A5

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens

Alignment Length:	558	Identity:	151/558 - (27%)
Similarity:	249/558 - (44%)	Gaps:	82/558 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCL 67
            ||...|.:.|.|.||...:|....:.|..:.|   |...:...|::.|.....|::.|...:..:
Human     6 EVTAFLGEWGPFQRLIFFLLSASIIPNGFTGL---SSVFLIATPEHRCRVPDAANLSSAWRNHTV 67

  Fly    68 PL----NRNISTPNTC-----------------------------------YSYNYELYM----- 88
            ||    .|.:  |::|                                   :.::.::|:
Human    68 PLRLRDGREV--PHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVT 130

  Fly    89 -----GYQS------------FPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLP 136
                 .|.:            .|::.:.||.|.||..|..|:||||.::||.:.|.|:|..||..
Human   131 EQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKN 195

  Fly   137 ILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVR----TLGLS 197
            :|.|...:....:.|.|:|.|..:|.:..::.|:...||:|..::|..|.:..|||    |||
Human   196 VLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLG-- 258

  Fly   198 ICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCL 262
            :||  ||..|.|..|..|..:|.||..|:..::|.::....:..:|||.:||||:.:::.|.|.:
Human   259 VCI--FYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 321

  Fly   263 KRVAKINGRHVEESAYAEFIEECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDA 327
            ::.||.||..|..:.:..  .|.:.....::.|.::|||.:|..:|..|::.....|.|::.|..
Human   322 RKAAKANGIVVPSTIFDP--SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFG 384

  Fly   328 VSRNVQGLGISPFVMFSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAAS 392
            :|.:...|....||...|||...:||.:|...|...:.|:...:.:|.|.|   ||   ::|...
Human   385 LSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGG---SV---LLFMQL 443

  Fly   393 ASDKTTTLLVSLSVVGRFGVTVAYNSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTR 457
            .......|...|.:||:||||.|::....|..||.||.||..||.....|....:..|.|.::..
Human   444 VPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLG 508

  Fly   458 SVFSPLPEIILGVLSLLGACLCLLLPETLHRTLPTSLE 495
            :....||.|::|.|::|.|.|.|.|||:....||.:::
Human   509 AYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	146/543 (27%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	51/153 (33%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	148/548 (27%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	121/383 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950