DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	553	Identity:	153/553 - (27%)
Similarity:	255/553 - (46%)	Gaps:	72/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLEVDKI---LEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPV 62
            ||:.|::   |.:.|.|.||...:|....:.|..:.|   |...::.:|::.|......::.|..
Mouse     1 MLDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGL---SAVFLTAIPEHRCRIPDTVNLSSAW 62

  Fly    63 DSSCLPLNR--NISTPNTC-----------------------------------YSYNYELYMGY 90
            .:..:|:..  ....|..|                                   :.|:.::::
Mouse    63 RNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWEYDKDIFL-- 125

  Fly    91 QSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAM-TG-NLLTI 153
            .:..:|.|.||.|.||..|..|.|:||.::||.:.|.|:|..||..||.:.  :|| || :.:.:
Mouse   126 STIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLT--MAMHTGFSFIQV 188

  Fly   154 WSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVR----TLGLSICIGFFYCLGSMAAPWI 214
            :|.|..:|.:...:.|:...||:|..::|..|.:..|||    |||  :||  |:..|.|..|..
Mouse   189 FSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLG--VCI--FFAFGFMVLPLF 249

  Fly   215 AVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYA 279
            |..:|.||..||..:||.::....:..:|||.:||||:.:...|.|.:::.||||| .|..|...
Mouse   250 AYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKING-IVAPSTIF 313

  Fly   280 EFIEECKCSQQNQK--ASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVM 342
            :..|..|....:.|  .|.|:.||.:||.:|..|::.....:.|::.|..:|.:...|..:.:|.
Mouse   314 DPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVN 378

  Fly   343 FSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASD---KTTTLLVSL 404
            ..|.|...:||.:|...|...:.|:...:.||.|.|..:     ::.....||   .:|||:
Mouse   379 CFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVL-----LLVQLVPSDLHYLSTTLV--- 435

  Fly   405 SVVGRFGVTVAYNSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILG 469
             :||:||:|.||:....|..||.||.||..||.....|....:..|.|.::..:....||.|::|
Mouse   436 -MVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMG 499

  Fly   470 VLSLLGACLCLLLPETLHRTLPTSLEDGENFGK 502
            .|::|.|.:.|..||:...:||.::::.:...|
Mouse   500 SLTILTAIITLFFPESSGVSLPETIDEMQKVKK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	146/526 (28%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	54/155 (35%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	148/531 (28%)
		MFS	123..513	CDD:119392	129/407 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950