DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and Slc22a28

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001013842.2	Gene:	Slc22a28 / 434674	MGIID:	3645714	Length:	552	Species:	Mus musculus

Alignment Length:	558	Identity:	136/558 - (24%)
Similarity:	240/558 - (43%)	Gaps:	82/558 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWC----ADGLPAS--------- 57
            ::|.:.|...|.|::.:.....:..|...|...:...:.:|.:.|    .|...||
Mouse     5 ELLNQVGSLGRFQILQISFVLFLVGLVVPHITMENFTAAIPNHRCWAPILDNDTASDNGSRILSQ 69

  Fly    58 -----IESPVDSS-----C----------LPLN---RNISTPNT--CY-SYNYELYMGYQSFPSE 96
                 |..|:||:     |          |.||   .|.:.|:|  |. .:.|:......:..:|
Mouse    70 DDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNETEPDTEPCVDGWVYDRSNFLSTIVTE 134

  Fly    97 MDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLF 161
            .|.||......::.:..|.:|..:|:::.|:|:|..||..||..|.|..........::.:..::
Mouse   135 WDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIY 199

  Fly   162 CMFRMISGIATDSNFVMMYILVMEYMRPSVRTLG----LSICIGFFYCLGSMAAPWIAVLMRSWR 222
            |:.|.::|::.:...|...:|::|:..|  :.||    |:.|..   .:|.|....:|.|.|.|.
Mouse   200 CLLRFLAGMSVEPISVNSNLLILEWTNP--KFLGMVAVLTSCAA---SIGYMILAGLAFLFRIWH 259

  Fly   223 GFLLTTSLPLLVVPFFYLI---VPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEE 284
            ...|..|:|:.   ||:::   :.||.:|||...|....:..|::||.:||  ::.|.....:|.
Mouse   260 HLQLAMSVPIF---FFFILTRWMSESARWLIVTNKPQKGLKELRKVAHMNG--MKNSGNTLTMEV 319

  Fly   285 CKCSQQNQ------KASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVM- 342
            .:.|.:|:      |:||.  |||.||.||....:|.|...:.|:....:|.::|.|..:..::
Mouse   320 VEASMKNELEAAKRKSSPR--DLFHTPILRNRICVLSFMRYLFTVSIFGLSLHLQHLSTNIILLR 382

  Fly   343 FSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVV 407
            |..||..||.:.:....| :.:||:......:.|.|||:...   :|..........::|:|:
Mouse   383 FLSSALGILISVIGHFVL-NHMGRRITQLVLMSLRGIFMLTA---VFVPQEMQTLRIIVVTLA-- 441

  Fly   408 GRFGVTVAYNS-----GAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEII 467
                  .|.:|     ...:..||:||.:|..|:..:.:.|.:..|.:...:...:..:.||.|.
Mouse   442 ------AALSSLCMCVSNLHINELLPTTLRATGMGVIGMFGNSGLFLAPLFMLLATYSANLPWIF 500

  Fly   468 LGVLSLLGACLCLLLPETLHRTLPTSLEDGENFGKNDR 505
            .|..|:|......|||||.::.||.|:.|..|..|:.|
Mouse   501 YGGFSILYGFSVFLLPETKNQPLPDSIHDVGNDWKDSR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	128/536 (24%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	38/156 (24%)
Slc22a28	NP_001013842.2	2A0119	11..525	CDD:273328	129/537 (24%)
Slc22a28	NP_001013842.2	MFS	151..516	CDD:119392	97/388 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940