DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and slc22a2

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	553	Identity:	151/553 - (27%)
Similarity:	258/553 - (46%)	Gaps:	68/553 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLEVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCAD------------- 52
            |...::|||:.|.|.|.|:.:...||::::..:..|.......|.|::||.|
Zfish     1 MTTFEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWS 65

  Fly    53 ---------------------------------GLPASIESPVDSSCLPLNRNISTPNTCY-SYN 83
                                             ||  |.|:| |........::....:|. .:.
Zfish    66 LQDARRATVPLINGSSGASYSQCGRFDVDWNATGL--SCENP-DGDFNQSQLSVMPMMSCVDGWE 127

  Fly    84 YELYMGYQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVAN-LIAMT 147
            |: |:|.|||.:|.|.||.|||.:.:.|:...:|.:|||:.:|||||..||:...::.| .|.:|
Zfish   128 YD-YVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMTNFFIGVT 191

  Fly   148 GNLLTIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMR-PSVRTLGLSICIGFFYCLGSMAA 211
            | :|...|.|.....:||.:.|......:::.|:|:.|.:. ...||:|::..:  |:.:|.:..
Zfish   192 G-ILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQL--FFSMGILLL 253

  Fly   212 PWIAVLMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEES 276
            |.:|..:.:||...:..::|.:....:|..:|||.:||:::.|...||...|.:||.|.:.:.:.
Zfish   254 PLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIAKENRKTLSKK 318

  Fly   277 AYAEFIEECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFV 341
                 ||..|....:..::...:|||:|.:||.:|.||.|......:.|..:...:..||.:.:|
Zfish   319 -----IETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQGLIMRLGILGGNVYV 378

  Fly   342 MFSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSV 406
            .|.:|....|||..||:...:||||:...:.:.:::|....:|      |...|....|..:::.
Zfish   379 DFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLIT------AFIPDSMFWLKSAVAC 437

  Fly   407 VGRFGVTVAYNSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSV-FSPLPEIILGV 470
            |||.|:|:|:.......|||.||.:|..||:............:.::|:..:| :..||.||.|.
Zfish   438 VGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGA 502

  Fly   471 LSLLGACLCLLLPETLHRTLPTSLEDGENFGKN 503
            |:.:...|.||||||....||.:::|.|:..:|
Zfish   503 LAFVAGGLVLLLPETKGVPLPETIDDIEHPNRN 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	142/528 (27%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	44/151 (29%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	144/530 (27%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	109/382 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950