DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and CG10486

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	185/600 - (30%)
Similarity:	296/600 - (49%)	Gaps:	94/600 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LEVDKILEKCGDFSRLQM---IMLLLFCVINVLSALHYYSQTIISFV-PKYWCADGLPASIESPV 62
            ::.|.:|...|.|.|.|:   :.::.||.|   :|..|..|..:... |||:|.  :|..:.:||
  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFI---TAFVYLGQIFMCLTPPKYYCY--VPELLHTPV 153

  Fly    63 DSSCLPLNRNISTP-------NTC--YSYNY---------ELYM-----------GY-------- 90
            :     |.:.:|.|       :.|  |:.||         ..|:           ||
  Fly   154 E-----LRKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRA 213

  Fly    91 -QSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIW 154
             :|...|..|:|.|....|..|.:||:||::|.:..|:.||..||:..|:.:..:|:.|:|.|..
  Fly   214 FESATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSM 278

  Fly   155 STNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAVLMR 219
            ||:...|.:.|.:.|.:.|:.|.|:||||:||:.|..|||..::.:..||...:|..||||:...
  Fly   279 STDFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAG 343

  Fly   220 SWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEE 284
            :||.|...||||:::..|.:.::|||.:||:|..:.|.|:..||.|.::|.:.|.:.....|  |
  Fly   344 NWRRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLF--E 406

  Fly   285 CKCSQQNQKASP----HLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGL-GISPFVMFS 344
            ..|:|..::...    .:|.:|:..|:.|:.:::....|.|:|.||...|....| ..:.|:.|:
  Fly   407 ASCTQFYKEELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFT 471

  Fly   345 LSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGR 409
            ::....||..:|:|...||.||:..:.....|||:| |:.|     ||..::....:.:|:  ||
  Fly   472 IACATELPGNILVILTLDRAGRRWCSFFYTSLSGVF-SLLG-----ASFQNRANMRMSALA--GR 528

  Fly   410 FGVTVAYNSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILF--TRSVFSPLPEIILGVLS 472
            |...:.||.|.|:|.|::||.||.||||.:|..|:.....|..:::  .:|:.|.|  |:||.|.
  Fly   529 FFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTL--IVLGALG 591

  Fly   473 LLGACLCLLLPETLHRTLPTSLEDGENFGKNDR-------------------WYTFSFLEGRTQS 518
            :.|..|.|.|||||:..||.:|.||..||||.|                   |:..|.|  ||.|
  Fly   592 IFGGLLALFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRKSHPRHNWHQGSSL--RTLS 654

  Fly   519 AATLDTQNAKMYSQS 533
            ..  :.:::|||.::
  Fly   655 KD--EFRSSKMYRKT 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	164/527 (31%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	54/149 (36%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	166/529 (31%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	127/382 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471412
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	8.010