DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	532	Identity:	142/532 - (26%)
Similarity:	235/532 - (44%)	Gaps:	70/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILEKCGDFSRLQMI---MLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDS---- 64
            :|:..|...|.|::   :|||.|   .|.|.|.:.|...:..|.:.|..  ||:...|..:
Mouse     6 LLDALGGVGRFQLVYTALLLLPC---GLLACHTFLQNFTAAAPPHHCQH--PANYTEPTTNVSGV 65

  Fly    65 ---SCLPLNRNISTPNTCYSY---NYELYMGYQS-------------------FPS----EMDWV 100
               :.:|||:: ..|..|..|   .:.|.....|                   |||    |.|.|
Mouse    66 WLRAAIPLNQH-GDPEPCRRYVEPQWALLKPNASSHGVATEGCKDGWVYDRSIFPSTIVMEWDLV 129

  Fly   101 CADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFR 165
            |.......|.||::..|.:||:.:.|.|||.:||...|:.:.|........|.:..:.:.:|:||
Mouse   130 CEARTLRDLAQSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGAATAYVGSFSAYCVFR 194

  Fly   166 MISGIATDSNFVMMYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSL 230
            .:.|:......:....||:|:|....||:. .|.:||.:.||.:....:|.|:|.||......|.
Mouse   195 FLMGMTFSGIILNSLSLVVEWMPTRGRTVA-GILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSA 258

  Fly   231 PLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVE-----ESAYAEFIEECKCSQQ 290
            |.||...:...:|||.:||:...|...||..|::||.:|||..|     ....:.:|::   ...
Mouse   259 PFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGERLTTEVVSSYIQD---EFA 320

  Fly   291 NQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAILPACL 355
            :.:.|..:||||:||.:||.|..|.......::.|..::.::|..|:|.:::.:|.....:||.|
Mouse   321 SVRTSNSILDLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAML 385

  Fly   356 LIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGA 420
            :.......:||:|..|:.|:|:|:.      :|......:...||....:.:|:..:..::....
Mouse   386 VATTTMIYVGRRATVSSFLILAGLM------VIANMFMPEDLQTLRTVQAALGKGCLASSFICVY 444

  Fly   421 QYATELIPTCVR--GQGVAAVH--VAGYAFTFFSAYILFTRSVFSP-LPEIILGVLSLL-GACLC 479
            .:..||.||.:|  |.|.|:|:  :.|..     |.::.|....|| ||.:..|..|:| |..:.
Mouse   445 LFTGELYPTEIRQMGMGFASVNARLGGLV-----APLITTLGEISPVLPPVSFGATSVLAGMAVA 504

  Fly   480 LLLPETLHRTLP 491
            ..|.||  |.:|
Mouse   505 CFLTET--RNVP 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	140/525 (27%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	46/153 (30%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	141/527 (27%)
		MFS	138..507	CDD:119392	105/383 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950