DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	152/544 - (27%)
Similarity:	250/544 - (45%)	Gaps:	65/544 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVD---SSCLP 68
            :|::.|...|.|:|.:.:.....:|.|.|...|...:.:|.:.|..  ||:.....|   .:.||
  Rat     6 LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRP--PANANLSKDGGLEAWLP 68

  Fly    69 LNRNISTPNTCYSYNY-----ELYMGYQ-------------------SFPSEM--DW--VCADAW 105
            |::. ..|.:|..:..     ..|.|.:                   :|||.:  :|  ||:...
  Rat    69 LDKQ-GQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSHRA 132

  Fly   106 KLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGI 170
            ...|.||::.||.::|:||.|||||.:||..:||:..|..........::.|.|::|:||::||:
  Rat   133 FRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGM 197

  Fly   171 ATDSNFVMMYILVMEYM----RPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLP 231
            :..|..:....|.:|:|    |..|.||     ||:.|.||......||..:..||...|..|:|
  Rat   198 SLASIAINCMTLNVEWMPIHTRAYVGTL-----IGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVP 257

  Fly   232 LLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEECKCSQQNQ---- 292
            ..:...:.....||.:|..|..:.|..:..|:|||:|||:. ||.|... ||..:.|.|.:
  Rat   258 FFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQ-EEGAKLS-IEVLRTSLQKELTLS 320

  Fly   293 KASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAILPA---C 354
            |.....::|.:.|.||...|.|.......:..|..:..::||.|:|.:::..:.....|||   |
  Rat   321 KGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVC 385

  Fly   355 LLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLL-VSLSVVGRFGVTVAYNS 418
            .|:|   :.:||:....|||||:||.|.|.|.|       .|:.|:: .||:|:|:..:..::|.
  Rat   386 FLVI---NSMGRRPAQMASLLLAGICILVNGII-------PKSHTIIRTSLAVLGKGCLASSFNC 440

  Fly   419 GAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLLLP 483
            ...|..||.||.:|..|:..........:..|..:..|...:..:|..|.|.:.::.:.:..|||
  Rat   441 IFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLP 505

  Fly   484 ETLHRTLPTSLED--GENFGKNDR 505
            |||.:.||.:::|  ..:.||.::
  Rat   506 ETLGQPLPDTVQDLKSRSRGKQNQ 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	146/521 (28%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	51/157 (32%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	148/523 (28%)
		MFS	135..505	CDD:119392	115/386 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950