DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	153/543 - (28%)
Similarity:	261/543 - (48%)	Gaps:	58/543 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPK-YWCADGLPASIE-----SPVD 63
            |:.|.|.|:|.|.|..:.||.|:..|..|..:.....:...|. |||......::.     ||.:
  Rat     5 DQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEE 69

  Fly    64 S----------------------------------SCLPLNR--NISTPNTCYSYNYELYMGYQS 92
            .                                  ||.||..  |.|.|....|.::.....:.:
  Rat    70 EWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVETHST 134

  Fly    93 FPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANL-IAMTGNLLTIWST 156
            ..|:.|.||.:||.|.|.|::..:|.:.|:..|||.||..|||.:.:::.. :.:|| ::..::.
  Rat   135 IVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVGITG-VVVAFAP 198

  Fly   157 NVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSW 221
            |.::|.:||.:.|:.....::..:::|.|.:....|.: :.|.|..|:.||.:..|.||....||
  Rat   199 NFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRI-VGIVIQMFFTLGIIILPGIAYFTPSW 262

  Fly   222 RGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEECK 286
            :|..|..|||..:...:|.:||||.:|||::::.:.|:..|:||||.||:|: .|.|:|.
  Rat   263 QGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHL-SSNYSEI----- 321

  Fly   287 CSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAIL 351
            .....:.::|..|||.:||::|:.||||.|......:.|..:...:..:|.:.::.|.:|....|
  Rat   322 TVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVEL 386

  Fly   352 PACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAY 416
            |..|||:...:|:||:...:||.:::|:...||      |...:....|..:::.:||.|:|:|:
  Rat   387 PGALLILLTIERLGRRLPFAASNIVAGVSCLVT------AFLPEGIPWLRTTVATLGRLGITMAF 445

  Fly   417 NSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILF-TRSVFSPLPEIILGVLSLLGACLCL 480
            .......:||.||.:|..||:............:.::|| ..:::..||.||.|:|:.:...|.:
  Rat   446 EIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVM 510

  Fly   481 LLPETLHRTLPTSLEDGENFGKN 503
            |||||....||.::||.|..|.:
  Rat   511 LLPETKGIALPETVEDVEKLGSS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	144/522 (28%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	45/150 (30%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	146/524 (28%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	113/381 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950