DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	161/555 - (29%)
Similarity:	254/555 - (45%)	Gaps:	74/555 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLEVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCAD------------- 52
            |..||.:||:.|:|...|....||.|:|:...|..|.....:.|.|.::|.:
  Rat     1 MPTVDDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYCQNPGVAELSQRCGWS 65

  Fly    53 ----------GLPASIESPVDSSCL---------------PL-----NRNISTPNTC-YSYNYEL 86
                      ||..|.|:...|.|:               ||     ||:......| :.:.|:
  Rat    66 QAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYD- 129

  Fly    87 YMGYQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLL 151
             ....|..:|.:.||.||||:.|.||...:|..:||:|:||:||..||...|:|..|:.....:|
  Rat   130 -TPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVL 193

  Fly   152 TIWSTNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAV 216
            |..:.:.|...:||::.|:.:..::|..|.|:.|::....|.. .:|.....:.:|.:....:|.
  Rat   194 TAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRT-TAILYQMAFTVGLVGLAGVAY 257

  Fly   217 LMRSWRGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEF 281
            .:..||...|..|||..:...:|..||||.:||:|:::...||..::::|:.||:..........
  Rat   258 AIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADLKMLC 322

  Fly   282 IEECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLS 346
            :||    ..::|.||...|||:||.||:||:||.:......:.|..:..:|...|.:.::.|..|
  Rat   323 LEE----DASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDFFYS 383

  Fly   347 ATAILPACLLIIALQDRIGRKAMASASLLLSG------IFISVTGGIIFAASASDKTTTLLVSLS 405
            :....||..:|:...|||||....:||.|::|      |||            ..:...|.|:|:
  Rat   384 SLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFI------------PHELHWLNVTLA 436

  Fly   406 VVGRFGVTVAYNSGAQYATELIPTCVRGQGV---AAVHVAGYAFTFFSAYILFTRSVFSPLPEII 467
            .:||.|.|:..........||.||.:|..|:   :|:...|..||.|..:.|.  .|:..||.|:
  Rat   437 CLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLM--EVWQALPLIL 499

  Fly   468 LGVLSLLGACLCLLLPETLHRTLPTSLEDGENFGK 502
            .|||.|....:.||||||....||.::|:.||.|:
  Rat   500 FGVLGLTAGAMTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	150/531 (28%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	44/149 (30%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	152/533 (29%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	123/410 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950