DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	534	Identity:	145/534 - (27%)
Similarity:	238/534 - (44%)	Gaps:	58/534 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCL 67
            ||...|.:.|.|.||...:|....:.|..:.:   |...::..|::.|......::.|...:..:
Mouse     6 EVTAFLGEWGPFQRLIFFLLSASIIPNGFNGM---SIVFLAGTPEHRCLVPHTVNLSSAWRNHSI 67

  Fly    68 PL----NRNISTPNTCYSY---------------------------------NYELYMGYQSFPS 95
            ||    .|.:  |..|..|                                 .|:..:...:..:
Mouse    68 PLETKDGRQV--PQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVT 130

  Fly    96 EMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTL 160
            |.|.||.|.||..|..|:||||.::||.:.|.|:|..||..:|.:...:....:.|.::|.|..:
Mouse   131 EWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEM 195

  Fly   161 FCMFRMISGIATDSNFVMMYILVMEYMRPSVR----TLGLSICIGFFYCLGSMAAPWIAVLMRSW 221
            |.:..::.|:...||:|..::|..|.:..|:|    |||  :||  ||..|.|..|..|..:|.|
Mouse   196 FTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLG--VCI--FYAFGFMVLPLFAYFIRDW 256

  Fly   222 RGFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEECK 286
            |..||..::|.::....:..:|||.:||||:.:...|.|.:::.|||||.....:.:..  .|.:
Mouse   257 RMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDP--SELQ 319

  Fly   287 CSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAIL 351
            .....:....|:.||.:|..:|..|::.....:.|::.|..:|.:...|....:|...|.|...:
Mouse   320 DLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEV 384

  Fly   352 PACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAY 416
            ||.:|...|...:.|:...||:|.|.|   ||   ::|......:...|..:|.:||:||:|.||
Mouse   385 PAYVLAWLLLQYLPRRYSISAALFLGG---SV---LLFMQLVPSELFYLSTALVMVGKFGITSAY 443

  Fly   417 NSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLL 481
            :....|..||.||.||..||.....|....:..|.|.::..:....||.|::|.|::|.|.|.|.
Mouse   444 SMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLF 508

  Fly   482 LPETLHRTLPTSLE 495
            .||:....||.:::
Mouse   509 FPESFGVPLPDTID 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	140/519 (27%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	50/153 (33%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	142/524 (27%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	121/398 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950