DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	527	Identity:	152/527 - (28%)
Similarity:	243/527 - (46%)	Gaps:	57/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVD---SSCLP 68
            :|::.|...|.|:|.:.:.....:|.|.|...|...:.:|.:.|..  ||:.....|   .:.||
Mouse     6 LLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRP--PANANLSKDGGLEAWLP 68

  Fly    69 LNRNISTPNTCYSYNYELYMGYQ-------------------SFPSEM--DW--VCADAWKLTLG 110
            |::. ..|.:|..:.:. :.|.:                   :|||.:  :|  ||:......|.
Mouse    69 LDKQ-GRPESCLRFPFP-HNGTEANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLA 131

  Fly   111 QSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRMISGIATDSN 175
            ||:|.||.::|:|:.|||||.:||..:||:..|..........::.|.|::|:||::||::..|.
Mouse   132 QSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASI 196

  Fly   176 FVMMYILVMEYM----RPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLVVP 236
            .:....|.||:|    |..|.||     ||:.|.||......||..:..||...|..|:|..|..
Mouse   197 AINCMTLNMEWMPIHTRAYVGTL-----IGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAF 256

  Fly   237 FFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAEFIEECKCSQQNQ----KASPH 297
            .:.....||.:|..|..:.|..:..|:|||:|||:. ||.|... ||..:.|.|.:    |....
Mouse   257 IYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQ-EEGAKLS-IEVLQTSLQKELTLNKGQAS 319

  Fly   298 LLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAILPA---CLLIIA 359
            .::|.:.|.|||..|.|.......:..|..:..::||.|:|.:::..:.....|||   |.|:|
Mouse   320 AMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVI- 383

  Fly   360 LQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQYAT 424
              :.:||:....|||||:||.|.|.|.|      ....|.:..||:|:|:..:..::|....|..
Mouse   384 --NSMGRRPAQLASLLLAGICILVNGII------PRGHTIIRTSLAVLGKGCLASSFNCIFLYTG 440

  Fly   425 ELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLLLPETLHRT 489
            ||.||.:|..|:..........:..|..|..|...:..:|..|.|.:.:..:.:..||||||.:.
Mouse   441 ELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQP 505

  Fly   490 LPTSLED 496
            ||.:::|
Mouse   506 LPDTVQD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	148/515 (29%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	53/157 (34%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	150/517 (29%)
		MFS	129..499	CDD:119392	118/385 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950