DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and Slc22a27

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	552	Identity:	134/552 - (24%)
Similarity:	237/552 - (42%)	Gaps:	63/552 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LEVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWC----ADGLPAS----- 57
            :...::|.:.|...|.|::.::...::|.:...|...:...:.:|.:.|    .|...||
Mouse    26 MSFQELLNQVGSLGRFQILQIVFLLLLNAIVVPHIAMENFTAAIPNHRCWVPILDNDTASDNGSR 90

  Fly    58 ---------IESPVDSSCLP---------------LN---RNISTPNT--CY-SYNYELYMGYQS 92
                     |..|:||:..|               ||   .|:|.|:|  |. .:.|:......:
Mouse    91 ILSQDDLLRISIPLDSNLRPEKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLST 155

  Fly    93 FPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTN 157
            ..:|.|.||......::.:..|.:|..:|.::.|:|:|.:||..||..|.|..........::.:
Mouse   156 IVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFILTCALLQFAITETCVAFAPS 220

  Fly   158 VTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLSICIGFFYC---LGSMAAPWIAVLMR 219
            ..::|..|.::|::.:...|..::|::|:..|..    |::......|   :|.|.:..:|.|.|
Mouse   221 FFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKF----LTMMAALLSCAPNIGYMISAGLAFLFR 281

  Fly   220 SWRGFLLTTSLPLLVVPFFYLI----VPESIQWLISKQKYDSAVVCLKRVAKINGRHVEESAYAE 280
            .|....||.|:|:    ||:||    :.||.:|||...|....:..|::||.:||.........|
Mouse   282 IWHHLQLTMSVPI----FFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGDLTME 342

  Fly   281 FIE-ECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVM-F 343
            .:. ..|...:..|..|.|.|||.|..||:...:|.|..:..|:....::.::|.|..:..:: |
Mouse   343 IVRTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFMRLFFTVSIFGLAVHLQHLSSNIILLQF 407

  Fly   344 SLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVG 408
            .:||.|||.:.:....| :.|||:......:.|.|||      |:.|.....:..||.:.::.:.
Mouse   408 LISALAILVSVIGPFVL-NHIGRRITYLVLMSLRGIF------ILIAVFVPQEMQTLRIIMATLA 465

  Fly   409 RFGVTVAYNSGAQYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSL 473
            ....::.......:..||:||.:|...|..:...|.:.:|.|...:...:.::.:|.|..|..|:
Mouse   466 EGISSLCVGVSRLHTNELLPTTLRATAVGVIGFFGNSGSFLSPLFMLLATYYANMPWIFYGGFSI 530

  Fly   474 LGACLCLLLPETLHRTLPTSLEDGENFGKNDR 505
            ..|....|||||.::.||.|..|..|..|..|
Mouse   531 FNAFTVFLLPETKNQPLPDSTHDVGNDWKESR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	126/526 (24%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	39/156 (25%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	104/420 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7627
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.890