Protein Alignment CG7342 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_001247196.1
• Gene: CG7342 / 42335
• FlyBaseID: FBgn0038716
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 138/588 - (23%)
• Similarity: 226/588 - (38%)
• Gaps: 129/588 - (21%)

  Fly     6 KILEKCGDFSRLQ-------MIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGL------PAS 57
            ::|:..|...|.|       |:.::..|..::|       :...:.||.:.|...|      .||
Human     5 ELLDLVGGLGRFQVLQTMALMVSIMWLCTQSML-------ENFSAAVPSHRCWAPLLDNSTAQAS 62

  Fly    58 IESPVDSSCL-----PLNRNISTPNTCYSYNYELYMGYQSFPSEMDW------VCADAWKL---- 107
            |...:....|     |...| ..|:.|..:....:.......:...|      .|.|.|..
Human    63 ILGSLSPEALLAISIPPGPN-QRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSI 126

  Fly   108 -------------------TLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTI 153
                               .:.||::..|.:||:...|..:|..||..:|..:.|..........
Human   127 FTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAA 191

  Fly   154 WSTNVTLFCMFRMISGIATDSNFVMM---------------------------YILVMEY----M 187
            ::....::|:||.:...|...  |||                           .:.|||:    .
Human   192 FAPAFPVYCLFRFLLAFAVAG--VMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAARA 254

  Fly   188 RPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLPLLV-VPFFYLI-----VPESI 246
            ||.|.||.   .:||.:..|..||  :|..:|.|      |.|.|:| ||||...     :.||.
Human   255 RPLVMTLN---SLGFSFGHGLTAA--VAYGVRDW------TLLQLVVSVPFFLCFLYSWWLAESA 308

  Fly   247 QWLISKQKYDSAVVCLKRVAKINGR-HVEESAYAEFIEECKCSQQNQKASPHLL-DLFQTPRLRR 309
            :||::..:.|..:..|.|||.|||: .|:::...|.:......:.:....|..| .|.:.|.||
Human   309 RWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLR- 372

  Fly   310 HTLILFFKSMVITLCYDA-------VSRNVQGLGISPFVMFSLSATAILPACLLIIALQDRIGRK 367
                  |::.:.|||:.|       ::.::|.||.:.|::........:||.:..:.|...:||:
Human   373 ------FRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRR 431

  Fly   368 AMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQYATELIPTCVR 432
            ...:|||||:|:.|.....:.....|      |..:|:|:|..||..|:.....|::||.||.:|
Human   432 PTLAASLLLAGLCILANTLVPHEMGA------LRSALAVLGLGGVGAAFTCITIYSSELFPTVLR 490

  Fly   433 GQGVAAVHVAGYAFTFFSAYILFTRSVFSP-LPEIILGVLSLLGACLCLLLPETLHRTLPTSLED 496
            ...|....:|..........:... .|..| ||.::.|.:.:|.....||||||....||.:::|
Human   491 MTAVGLGQMAARGGAILGPLVRLL-GVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQD 554

  Fly   497 GEN 499
            .:|
Human   555 VQN 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	133/572 (23%)
		MFS	93..>243	CDD:119392	46/215 (21%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	135/574 (24%)
		MFS	122..541	CDD:119392	107/445 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153254
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950