DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7342 and slc22a8

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	135/533 - (25%)
Similarity:	239/533 - (44%)	Gaps:	52/533 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCA---DGLPASI--ESPVDSS 65
            ::||:.|...|.|:..::|.|...:|.|.|...|...:.:|.:.|.   .|..::.  |:..:..
Frog     5 ELLERTGGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIPDHKCKANDTGYQSNSTDETGYERL 69

  Fly    66 CLPLNRNISTPNTCYSY----------------NYEL-----YMGYQ----SFPS----EMDWVC 101
            ..||:.| ..|:.|..|                :.||     .:|::    .|.|    |.|.||
Frog    70 SAPLDAN-GQPDRCLEYVEIQWRMVGSNSTWNNSSELATRPCTIGWEYSKDEFSSTIITEWDLVC 133

  Fly   102 ADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNVTLFCMFRM 166
            ....:..|.||::..|.:||:::||.|:|..||..:||.:........:...:|.|...:|:||.
Frog   134 GRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQLAVSGVCAAFSPNYLSYCIFRF 198

  Fly   167 ISGIATDSNFVMMYILVMEYMRPSVRTLGLSICIGFFYCLGSMAAPWIAVLMRSWRGFLLTTSLP 231
            ::|:|.....:....|::|::...|||:..::. ||.|..|.:....:|..||.||...|..|||
Frog   199 LTGMALSGIGLNTTALIVEWVPTRVRTVTGTLA-GFSYTAGQLLLAGLAYGMRDWRWLQLCVSLP 262

  Fly   232 LLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKINGRHVE------ESAYAEFIEECKCSQQ 290
            ..:...:....|||.:||:...|.:.||..:::||.:||:..|      ||..:|.|:|.    .
Frog   263 FFIYFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKKEEGEKITLESLKSEMIKEL----A 323

  Fly   291 NQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAVSRNVQGLGISPFVMFSLSATAILPACL 355
            :.|:|..::||.:|..:||.:..|.......:..|..::.::|...:|.:::..:......||.|
Frog   324 SAKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVSIYLIQVIFGAVDFPAKL 388

  Fly   356 LIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGA 420
            :.......:|||.....||:|.||      .||......::..|:..||:|.|:..:..:::...
Frog   389 VSATAMIYVGRKFTQFMSLILGGI------AIIANIFVPNELQTVRTSLAVFGKGCLAASFSCIF 447

  Fly   421 QYATELIPTCVRGQGVAAVHVAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLLGACLCLLLPET 485
            .|.|||.||.:|..|:.............:..:.....::..:|.:|.|...::.......||||
Frog   448 LYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPIISGLCVFFLPET 512

  Fly   486 LHRTLPTSLEDGE 498
            :::.||.::|:.|
Frog   513 VNKPLPDTIEEVE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	129/518 (25%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	45/153 (29%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	105/415 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100