DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	566	Identity:	141/566 - (24%)
Similarity:	242/566 - (42%)	Gaps:	57/566 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSVYE 67
            |.|||.:.|::||||:.:|:|....|.|...::|:...:.....|.|        :|..:::...
Human     4 FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHC--------AVAWVKNHTF 60

  Fly    68 NISASSCTPLLGVVNGTG---------VVSTNRKCRNWIFNR-------ESGYE-------SITT 109
            |:||:....|...::..|         ....|...::.:.:|       :.|:|       |:..
Human    61 NLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENRLPSLKN 125

  Fly   110 ELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGR----LPSLLMATLCGATGDFITSF-V 169
            |...|||:.|.....||.|..|.:|||::||.|.|::||    |..||:.||.|....|:.|| :
Human   126 EFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFEL 190

  Fly   170 HTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGN 234
            :....||.:..::|||...:     .|:.|::.|..||..: ::....:..|.|.....|....|
Human   191 YMALRFAVATAVAGLSFSNV-----TLLTEWVGPSWRTQAV-VLAQCNFSLGQMVLAGLAYGFRN 249

  Fly   235 WRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYY 299
            ||......:.|.|.:..|.:.:.|||:||||:.:.|:|:..::|.|..|||.:...:.::.|.
Human   250 WRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVP-- 312

  Fly   300 RERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFT 364
                    :........|.:|..|:||:.||.:.....:.:|....::..:...|...:......
Human   313 --------EKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIF 369

  Fly   365 SIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGA 429
            ..|.:||..:.:.:..:.|||......|.:|||:.....|:     |.:..:::.::..:|:...
Human   370 GAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFI-----PADLPVVVTMLAVVGKMAT 429

  Fly   430 TVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGAG 494
            ..::.....|:||:.||.:|...:..:.:.......|...||.|.:|:..||.:....|......
Human   430 AAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGL 494

  Fly   495 LCLTLPETLNKKLPETLADGEKFALNESFLYFPCFSRKEKNVRTES 540
            ||..||||..:.|.:||.|.|......|....|.....|...||.|
Human   495 LCTLLPETHGQGLKDTLQDLELGPHPRSPKSVPSEKETEAKGRTSS 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	127/526 (24%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	93/377 (25%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	127/526 (24%)
		MFS	139..500	CDD:119392	94/381 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		9/30 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153612
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950