DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	539	Identity:	142/539 - (26%)
Similarity:	226/539 - (41%)	Gaps:	47/539 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSV 65
            |.||::||:.|:.|.||.:.:.:.|...:..:.|...|.....||.|.| ....|..:...:..:
Human     1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC-RPPHNASTGPWVLPM 64

  Fly    66 YENISASSCTPLLGVVNGTGVVSTNRKCR----NWIFNRESGYESITTELKWVCDKSHHPAVGQS 126
            ..|.....|...:...|.:....|.|...    .|::|  |..:||.||...||:.:....:.||
Human    65 GPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYN--STKDSIVTEWDLVCNSNKLKEMAQS 127

  Fly   127 FFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFMSGLSTDTMYY 191
            .|..|.::|.::.|.|||:.||.|.|..:.|..|......:|..|.|.:...||:.|.....:..
Human   128 IFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITL 192

  Fly   192 LMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWL---ASLPALGVLIYP 253
            ...||..|::..:.|.. ::..|...|.||....|..|..|..||   ||   .|:|.....:..
Human   193 STVILNVEWVPTRMRAI-MSTALGYCYTFGQFILPGLAYAIPQWR---WLQLTVSIPFFVFFLSS 253

  Fly   254 FLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYYRER-ELQDYKLNSHEDTFL 317
            :...||.:||:...|...|:..|::||.||.:..|           .|| .|::.|||..::..|
Human   254 WWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEE-----------GERLSLEELKLNLQKEISL 307

  Fly   318 A--------MFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPAGVA 374
            |        :|..|.|||.|..|.:.......:...:...:|..|.:.:.|......|.:||...
Human   308 AKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFI 372

  Fly   375 ILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSYDAEIQY 439
            .:|..:.:||......||.:.|....|..|:     |.:...:..::...|:...:.|:.....|
Human   373 TILSLSYLGRHTTQAAALLLAGGAILALTFV-----PLDLQTVRTVLAVFGKGCLSSSFSCLFLY 432

  Fly   440 AAEIIPTSVR--GQAVSNIHV-IGLASSSLAFYVIYLAQYYKP-LPSIFISCLMFFGAGLCLTLP 500
            .:|:.||.:|  |..|||:.. :|    |:...::.:....:| :|:|........|....|.||
Human   433 TSELYPTVIRQTGMGVSNLWTRVG----SMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLP 493

  Fly   501 ETLNKKLPETLADGEKFAL 519
            ||||:.||||:.|.|.::|
Human   494 ETLNQPLPETIEDLENWSL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	132/518 (25%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	97/388 (25%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	132/518 (25%)
		MFS	96..493	CDD:119392	107/422 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950