DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	551	Identity:	146/551 - (26%)
Similarity:	246/551 - (44%)	Gaps:	56/551 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNG-LSVEGIRS 64
            |.|..||.:.|.:.:||.::|.:.....::..||:.....|:..|.|.|....|:| .|..|...
Zfish     1 MRFEDVLREIGGFNKFQFLVLYILWLPRVILPLHFLLHNFISGVPPHHCALPRLDGRFSASGAEK 65

  Fly    65 VYENI--------------SASSC----TPLLGVVNG-TGVVSTNRK-----CRN-WIFNRESGY 104
              |.:              |.|||    .|:...:|| ..|:..||.     |:| |:::|....
Zfish    66 --EELAQIVALGIPRNSDGSYSSCKMYTMPMDFDLNGDLSVLYGNRSNVSVPCQNGWVYDRSQFT 128

  Fly   105 ESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFV 169
            .:..||...|||.........:|||:|..:|.::||.|||:.||.|.:.::.:..|....|.:|.
Zfish   129 STTATEWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSFVSSAVFGIIEAFS 193

  Fly   170 HTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGN 234
            .:...||.:|.:.|.:...|......|..|:...|.||| ...|:::.:..|.|.....|..|.:
Zfish   194 SSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTF-TGTIISLGWSVGNMLLALLAYLIRD 257

  Fly   235 WRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYY 299
            ||..:.:.:.|.|..:|..:.|.|||:|||...:.::|...|...||.|.::          .|.
Zfish   258 WRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGKY----------SYT 312

  Fly   300 RERELQDY-KLNSHED-----TFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPF 358
            ::.::::. |:...||     ::|.:..||:||:..|...:....:..:...|:.|:.|.|.:.:
Zfish   313 KKLDIENLKKITIAEDSNKNHSYLDLVRTPKLRKIVLCSGIFWFAVAFTYYGISFNITGFGLNIY 377

  Fly   359 KLFSFTSIVYLPAGVAILLLQNKIGRK-GMACTALFVGGLITTATGFMIAHLDPTENALLLAIMV 422
            .......::.:||.|...|..::|||: |.|.:.:..|.||.      :..:.|||.|.:...:.
Zfish   378 LTQFIYGVIEVPAKVGTYLTLDRIGRRNGQAWSLIIAGALIG------LNSVIPTEFAAVRTGIA 436

  Fly   423 GLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQ--YYKPLPSIFI 485
            .:|:..:..::.....|.:|:.||.:|...:.....|.....|||..||....  :|.| |.:|.
Zfish   437 VIGKGFSEAAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVILFEDIWHYGP-PVVFS 500

  Fly   486 SCLMFFGAGLCLTLPETLNKKLPETLADGEK 516
            :..:|.|..:.| ||||.|.:|||.:.|.|:
Zfish   501 ATAVFSGCVVFL-LPETTNVQLPENILDVEE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	139/533 (26%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	98/381 (26%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	138/532 (26%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	98/384 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960