DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Sv2a

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_071313.1	Gene:	Sv2a / 64051	MGIID:	1927139	Length:	742	Species:	Mus musculus

Alignment Length:	548	Identity:	111/548 - (20%)
Similarity:	186/548 - (33%)	Gaps:	187/548 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 FMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFMSGLSTDTMYYLM 193
            ::|.:||..::|.|:|::||...||::....:...|.:|||.....|.|.|.:||:.......::
Mouse   212 YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIV 276

  Fly   194 YILVFEYLSPKSRTFGLNIILAVFYCFG---LMTSPWAAI----W---------IGNWRRYLWLA 242
            :....|:|:.:.|...|: .|.:|:..|   .....||.|    |         ..:||.::.:.
Mouse   277 FSYFSEFLAQEKRGEHLS-WLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVC 340

  Fly   243 SLP---ALGVL-IYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRR---HVEESVFDEFVKYYR 300
            :.|   |:|.| ..|    ||.::.|...|:|:|.:.||:|...|.|   | .|.||.  |.:.:
Mouse   341 AFPSVFAIGALTTQP----ESPRFFLENGKHDEAWMVLKQVHDTNMRAKGH-PERVFS--VTHIK 398

  Fly   301 ERELQDYKLNSHEDT---------------------FLAMFLTPRLRRFTLTLL----------- 333
            ....:|..:....||                     ||:.| :|..||.||.::
Mouse   399 TIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF-SPEYRRITLMMMGVWFTMSFSYY 462

  Fly   334 ----------------------------------------------------------VKSVI-- 338
                                                                      :|||.
Mouse   463 GLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFE 527

  Fly   339 -----------ITLS------CDVIN------------------------RNME-------GLGT 355
                       :|.|      |..||                        .|.|       |.|.
Mouse   528 DSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGE 592

  Fly   356 SPFKLF--SFT-SIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALL 417
            ..:.::  ||. ::..||..:...||.:||||..|     ..|..:.:...........:|:|::
Mouse   593 GAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRM-----LAGSSVLSCVSCFFLSFGNSESAMI 652

  Fly   418 LAIMVGLGRFG--ATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVI-YLAQYYKP 479
            ..:.:    ||  :..|::|......|:.|:..|..|...::.:...::.|...:. ......|.
Mouse   653 ALLCL----FGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKA 713

  Fly   480 LPSIFISCLMFFGAGLCLTLPETLNKKL 507
            .|.:|.|..:..|:.|.|.||||..:.|
Mouse   714 APILFASAALALGSSLALKLPETRGQVL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	111/548 (20%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	106/538 (20%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	111/548 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..145
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910