DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	560	Identity:	153/560 - (27%)
Similarity:	234/560 - (41%)	Gaps:	76/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSV 65
            :|:.:|....|.:|.||.:|..|...:.|.......|...:|..|||.|...|...||     |.
Mouse     2 LDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPEHRCRIPDTVNLS-----SA 61

  Fly    66 YENISASSCTPLLGVVNGTGVVSTNRKCR---------------------------------NWI 97
            :.|.|....|.     :|..|   .:|||                                 .|.
Mouse    62 WRNHSIPMETK-----DGPEV---PQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWE 118

  Fly    98 FNRESGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATG 162
            ::::....:|.||...||.......:..|||::|.::|:.|.|.|||:.|| .::|..|:...||
Mouse   119 YDKDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGR-KNILFLTMAMHTG 182

  Fly   163 -DFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSP 226
             .||..|......|.....:.|:...:.|...::|..|.||...|.....:.:.:|:.||.|..|
Mouse   183 FSFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVLP 247

  Fly   227 WAAIWIGNWRRYLWLASLPALGVLIYP--FLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEE 289
            ..|.:|..|||.|...:||  |||...  :.|.||.:||:::.:..:|.:.::|.||.|......
Mouse   248 LFAYFIREWRRLLLAITLP--GVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPS 310

  Fly   290 SVFDEFVKYYRERELQD---YKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIIT-----LSCDVI 346
            ::||.    ....:|||   .|..||.  ...:..||.:|..|:..::..:.|:     ||.|..
Mouse   311 TIFDP----SETNKLQDDSSKKPQSHH--IYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTP 369

  Fly   347 NRNMEGLGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDP 411
            |.|    |......| ..:.|.:||.|...||...:.|:.....:||:||.:     .::..|.|
Mouse   370 NLN----GNIYVNCF-LLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSV-----LLLVQLVP 424

  Fly   412 TENALLLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQY 476
            ::...|...:|.:|:||.|.:|.....|.||:.||.||...|..........|.|:.|.:||..|
Mouse   425 SDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAY 489

  Fly   477 YKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETLADGEK 516
            .:.||.|.:..|....|.:.|..||:....||||:.:.:|
Mouse   490 DRRLPYILMGSLTILTAIITLFFPESSGVSLPETIDEMQK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	148/542 (27%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	113/383 (30%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	148/542 (27%)
		MFS	123..513	CDD:119392	118/408 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950