DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	560	Identity:	139/560 - (24%)
Similarity:	232/560 - (41%)	Gaps:	77/560 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLI-TFT---PEHWCF-HADLNGLSVE 60
            |.||::|::.|..|.||.:.:|    |.||..|...||.|: .|:   |.|.|: |...||.:|
Human     1 MAFSKLLEQAGGVGLFQTLQVL----TFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV- 60

  Fly    61 GIRSVYENISASSCTP--LLGVVNGTGVVSTNRKCR----------------------------- 94
                      :::.||  ||.:....|......:||
Human    61 ----------STNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVD 115

  Fly    95 NWIFNRESGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCG 159
            .|:::|.....:|..:...||.......:.||.|..|.:||:.|:|.||.:.||.|.|....|..
Human   116 GWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQL 180

  Fly   160 ATGDFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMT 224
            |.....|.|..|...:...||::......::.....|:.|:.:...|...:.::...|.. |...
Human   181 AVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSA-GQAA 244

  Fly   225 SPWAAIWIGNWRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEE 289
            ....|..:.:||.....||:|...:.:..:.:.|||:||:.|.|.|.|:..|:|||:.|.....:
Human   245 LGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAK 309

  Fly   290 SVFDEFVKYYRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLG 354
            ::..|.:....:.|:...|   ...:.|.:|..|.||..:..:||.:..:.:|...:..:::.||
Human   310 NLTIEVLMSSVKEEVASAK---EPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLG 371

  Fly   355 TSPFKLFS-FTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLL 418
            ...|.|.: |.::.:|......||| :.:||:.:...:..:.||...|.  |:...|.....::.
Human   372 RDIFLLQALFGAVDFLGRATTALLL-SFLGRRTIQAGSQAMAGLAILAN--MLVPQDLQTLRVVF 433

  Fly   419 AIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSI 483
            |:: |.|.||  :|......|.||:.||.||..|...:|.:|...:.:...::...|....||.:
Human   434 AVL-GKGCFG--ISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPL 495

  Fly   484 FISCL--------MFFGAGLCLTLPETLNKKLPETLADGE 515
            ....:        :||       ||||....||:|:.|.|
Human   496 LYGVISIASSLVVLFF-------LPETQGLPLPDTIQDLE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	132/543 (24%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	93/381 (24%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	132/543 (24%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950