DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and slc22a2

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	597	Identity:	163/597 - (27%)
Similarity:	256/597 - (42%)	Gaps:	105/597 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWC------------------ 49
            |.::|::.|.:||.|:.|...:...:|..|..|.......|||||||
Zfish     4 FEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWSLQD 68

  Fly    50 ----------------------FHADLN--GLSVEGIRSVYENISASSCTPLLGVVNGTGVVSTN 90
                                  |..|.|  |||.|.....: |.|..|..|::..|:|
Zfish    69 ARRATVPLINGSSGASYSQCGRFDVDWNATGLSCENPDGDF-NQSQLSVMPMMSCVDG------- 125

  Fly    91 RKCRNWIFNRESGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMA 155
                 |.:: ..|.:|..||...||..:.:..:.|:...:|.:||:|..|||:|:.||:.|.||.
Zfish   126 -----WEYD-YVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMT 184

  Fly   156 T-LCGATGDFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLS-PKSRTFGLNIILAVFY 218
            . ..|.||..:.:..:.:....| |.:.|......:.:.|:|:.|.:. ...||.|  :...:|:
Zfish   185 NFFIGVTGILVATSPNYISLLVF-RALFGFGVKGGWMVGYVLITELVGVDHRRTVG--VTYQLFF 246

  Fly   219 CFGLMTSPWAAIWIGNWRRYLWLA---SLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVA 280
            ..|::..|..|.:|.|||   ||.   ::|.:..|.|.:.|.||.:||||:.|..:||...|.:|
Zfish   247 SMGILLLPLLAYFITNWR---WLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAEAVEITKSIA 308

  Fly   281 KFNRRHVEESVFDEFVKYYRERELQDYKLNSHED-TFLAMFLTPRLRRFTLTL---------LVK 335
            |.||:.:.:.:          ..|:|..::|... :|:.:|.|.:||.:|..|         :.:
Zfish   309 KENRKTLSKKI----------ETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVYQ 363

  Fly   336 SVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITT 400
            .:|:.|..         ||.:.:..|..:.||.|||...|||...:|||:....||..|.|....
Zfish   364 GLIMRLGI---------LGGNVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACL 419

  Fly   401 ATGFMIAHLDPTENALLLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSS 465
            .|.|:     |.....|.:.:..:||.|.|::::..:....|:.||.:|...||....:......
Zfish   420 ITAFI-----PDSMFWLKSAVACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGI 479

  Fly   466 LAFYVIY-LAQYYKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNESFLYFPCF 529
            :|.:::| ||..:..||.|....|.|...||.|.||||....||||:.|.|....|:.   .|..
Zfish   480 VAPFLLYRLAVIWLELPLIIFGALAFVAGGLVLLLPETKGVPLPETIDDIEHPNRNKE---NPQQ 541

  Fly   530 SRKEKNVRTESV 541
            |::.:|:.|..|
Zfish   542 SQQLENLMTSDV 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	151/556 (27%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	109/388 (28%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	151/556 (27%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	110/398 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950