DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and SLC22A

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	132/550 - (24%)
Similarity:	233/550 - (42%)	Gaps:	62/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCF--HADL-------------- 54
            :|...|.:||||::|.||.....:..::...:......|..|.|.  ..||
  Fly    30 ILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHTNWSI 94

  Fly    55 --NGLSVEGIRSVYENISASSCTPLLGVVNGTGVVSTNRKCRNWIFNRESGYESITTELKWVCDK 117
              ||..::.... |.|.........:.:.:..........|.:..|.......:|:.:....||.
  Fly    95 PKNGKDLDSCNR-YTNSELPQWNHSVDICSADHFTKNKEACAHNEFVFRDDEVTISNDFGIFCDD 158

  Fly   118 SHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFMS 182
            ....::..:...:|...|..|.|:::|:.||..|:.:..:.||....|.||..:..||....|:.
  Fly   159 EWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLD 223

  Fly   183 GLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLASLPAL 247
            .:::.|:|...:::..|.:.||.|....::| .|||..|.:....:|....:||..|.:...|:|
  Fly   224 NMTSSTLYSTCFVIGIELVGPKRRVLACSVI-TVFYAVGEVLLAMSAKAFHDWRILLRITYGPSL 287

  Fly   248 GVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYYRERELQDYKLNSH 312
            .:|.|.:::.||.:|||::.|.:.|...|::.|..|:|.:.|||.|:.|...|::..|     |.
  Fly   288 ILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKLVLANRDKLQQ-----SS 347

  Fly   313 EDTFLAMFLTP----------RLRRFTLTLLVKSVI-ITLSCDVINRNMEGLGTSPFKLFSFTSI 366
            |..|      |          |:...:|..:|..:: ..||.:|:.     |....:..|::.::
  Fly   348 ESRF------PIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVL-----LDGDKYNNFAYIAL 401

  Fly   367 VYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATV 431
            |.:|.....||:.::.||:...|..:...||....|.|..|     :..:|..::..:|:...|.
  Fly   402 VEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGA-----DQPVLQLVLFLVGKLTITA 461

  Fly   432 SYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGAG-- 494
            |:.....:|:||.||::|...:|...::|...|.||.....||:||...|:     ::|.||.
  Fly   462 SFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPA-----MLFAGAAIV 521

  Fly   495 ---LCLTLPETLNKKLPETLADGEKFALNE 521
               |.|..|||.|..||.|:.:.:...:.:
  Fly   522 SGLLTLFFPETTNVVLPTTVQEADAIGVKK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	130/532 (24%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	102/388 (26%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	130/532 (24%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	105/410 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458505
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940