DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and slc22a4

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	560	Identity:	155/560 - (27%)
Similarity:	243/560 - (43%)	Gaps:	89/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITF---TPEHWCFHADLNGLSVEGIR 63
            |:..:....|.:|.||:.:.|....:.:...   |....|.|   ||.|.|...:...:|
Zfish     3 DYDDITSFLGTWGPFQLTVFLALAISILPNG---FVGLYIVFVGDTPAHECLIPEQINIS----- 59

  Fly    64 SVYEN-----------ISASSCTPL-------LGVVNGTGVVSTN------RKC-RNWIFNRESG 103
            ||:.:           :..|||:..       |.::|.|..|..|      ..| ..|.:::|..
Zfish    60 SVWRDAAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIETEPCVDGWSYSQEFY 124

  Fly   104 YESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSL--LMATLCGATGDFIT 166
            ..:|.||...||::.:...:..|.:|.|.:|||.:.|.:||:.||.|.|  :||.      ..||
Zfish   125 QSTIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMAL------QTIT 183

  Fly   167 SFVHTL--PWFAFSR--FMSGLSTDTMYYLMYILVFEYLSPKSRT-FGLNIILAVFYCFGL--MT 224
            ..:...  .|..||.  |..|.|..:.|.:.|:|..|.|||.||. ||   .|.||...|:  |.
Zfish   184 ILIQMFSPSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFG---SLGVFMGSGIGQMF 245

  Fly   225 SPWAAIWIGNWRRYLWLASLPAL-GVLIYP--FLICESAQWLLTKRKYDDAVICLKKVAKFNRRH 286
            .|.||.:|.:||   ||....|| |:|.:|  :.|.||.:|||::.:..:|...|::.|:.||..
Zfish   246 FPLAAYFIRSWR---WLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVT 307

  Fly   287 VEESVF------DEFVKYYRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKS---VIITLS 342
            ..|.:|      :...|..::..:.|...|.:.               ..|:|:.|   ::||:|
Zfish   308 APEVIFSSSEIEEAAKKRIQKHSILDILSNCNA---------------VSTILICSLLWMVITMS 357

  Fly   343 CDVINRNMEGLGTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIA 407
            ...:..|...|..:|:..|..:::|.:||.:...||.....|:....:.|.:||.:     ..|.
Zfish   358 YYALILNTTNLHGNPYLNFFLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGAL-----IFII 417

  Fly   408 HLDPTENALLLAIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIY 472
            .|.|||...|...:..||:...|.::.......:|:.||.||..|:.:..:.....|.::.::||
Zfish   418 QLIPTELQGLATALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIY 482

  Fly   473 LAQYYKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETLA 512
            |..||:.:|.|.|..|..|...:.|.|||:..|.||||:|
Zfish   483 LGNYYRYIPYIVIGGLALFSGVMSLLLPESKGKVLPETIA 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	151/547 (28%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	114/393 (29%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	151/547 (28%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	114/397 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950