DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and CG42269

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	196/567 - (34%)
Similarity:	311/567 - (54%)	Gaps:	40/567 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPE-HWCFHADLNGLSVE---G 61
            |||..:|...|.:||:|.::.:.....:...:..||||..:|..|| |||...:|:||.||   .
  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLA 134

  Fly    62 IRSVYENISASSCTPLLGVVNGTGVVSTNR----------KCRN-WIFN-RESGYESITTELKWV 114
            :.....|...::|  .:..||.|.:::..:          |||: |.:| .|..|.::.||..||
  Fly   135 LSIPMTNGEYNNC--YMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWV 197

  Fly   115 CDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSR 179
            ||.:..|...||.||:|::||.::||:::|:.||:|:|:...:.|......|:||.....||..|
  Fly   198 CDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMR 262

  Fly   180 FMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLASL 244
            |..|.:.|..:.:|||||.||:.||.|||..|:.:|:|:.......||.|.::.:|:....:.|.
  Fly   263 FFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSA 327

  Fly   245 PALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEE---SVFDEFVKYYRERELQD 306
            |.|..:..||::.|||:||:::.|.|.||..|||:.|.|.|.|..   .:|.:..|..:|:|.|:
  Fly   328 PLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQEQEAQN 392

  Fly   307 YKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPA 371
            .|.     :.|.:|.:|||||.||.|:|..:.|:|..|...||:..||...|..|:......|||
  Fly   393 GKY-----SVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPA 452

  Fly   372 GVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSYDAE 436
            ...:.::.::.||:.:||:::.:.|:.:     ::|.:.|.  .:..|.:..:|||...:||:..
  Fly   453 DTLLTVILDRFGRRWLACSSMVLSGVFS-----LLATVVPV--GIYSAALAIMGRFFVNISYNIG 510

  Fly   437 IQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGAGLCLTLPE 501
            :|:|||::||.||.|||:.||::|..:|.:|.:|:|||...:.||.|.:..|...|..|.|.|||
  Fly   511 LQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPE 575

  Fly   502 TLNKKLPETLADGEKFALNESFLYFPCFSR-------KEKNVRTESV 541
            |||..||:||:|||:|...:|...|||.::       :::|...|.|
  Fly   576 TLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEV 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	179/517 (35%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	132/375 (35%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	164/485 (34%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	122/350 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471423
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.960