DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and CG10486

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	172/559 - (30%)
Similarity:	286/559 - (51%)	Gaps:	42/559 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFT-PEHWCFHADLNGLSVEGIRS 64
            :||..:|...|.:||||:.:.|.......:.:..|..|..:..| |:::|:..:|....||..:.
  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKE 158

  Fly    65 V----YENISASSC-------TPLLGVVNGTGVVSTNR---KC-RNWIFNRES-GYESITTELKW 113
            :    .::.|.|.|       |.:....|.:..::|:.   .| :.::|.:|. .:||.|.|..|
  Fly   159 LSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATMEFGW 223

  Fly   114 VCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFS 178
            :||...:....|..||:||::|.:.:|:.:|..||:.:|:.:......|...||.......||.|
  Fly   224 LCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFTFAIS 288

  Fly   179 RFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLAS 243
            ||:.|.|.||.:.::||||.||:.||.||...|:.||:||....|..||.|:..|||||:....|
  Fly   289 RFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFSSFTS 353

  Fly   244 LPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEF----VKYYREREL 304
            ||.:..:....|:.|||:||::..:.|.|:..||.|.:.|::.|.:.:.|.|    .::|:|
  Fly   354 LPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFYKE--- 415

  Fly   305 QDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGT-SPFKLFSFTSIVY 368
               :|:..:.|.|::|...|:.|:.:.:::..:.|:|..|...|....|.: :.|..|:......
  Fly   416 ---ELDGRDFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTIACATE 477

  Fly   369 LPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSY 433
            ||..:.::|..::.||:.  |:..:     |:.:|.........:|...:.:....|||.:.:.|
  Fly   478 LPGNILVILTLDRAGRRW--CSFFY-----TSLSGVFSLLGASFQNRANMRMSALAGRFFSNICY 535

  Fly   434 DAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPS--IFISCLMFFGAGLC 496
            :..:|:||||:||.||.|.|:.||.:|..:..::..|:||::  |.|.|  |.:..|..||..|.
  Fly   536 NIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSK--KSLSSTLIVLGALGIFGGLLA 598

  Fly   497 LTLPETLNKKLPETLADGEKFALNESFLYFPCF---SRK 532
            |.||||||.:|||||:||.:|..|:...:.||.   |||
  Fly   599 LFLPETLNHELPETLSDGAQFGKNQRIWHMPCCGPGSRK 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	157/522 (30%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	118/379 (31%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	157/522 (30%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	119/385 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471414
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.960