DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	137/536 - (25%)
Similarity:	230/536 - (42%)	Gaps:	59/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSQVLDKCGNYGRFQVMILLLYGYTNILGSL----HYFSQTLIT----FTPEHWCFHADLNGLSV 59
            |:.||...|.:|.||..::.|....:||.:.    |:|   |:|    :....|......|....
  Rat    51 FASVLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHF---LLTAQRPYCNTSWILQVGPNLTED 112

  Fly    60 EGIR-SVYENISASSCTPLL---------GVVN-GTGVVSTNRKCRN-WIFNRESGYESITTELK 112
            |.:. :|....:.|..|.|:         .:|: |.....|   |:: ||: ..:...|:|.|..
  Rat   113 EQLNLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTET---CKHGWIY-PFAHTRSLTNEFD 173

  Fly   113 WVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAF 177
            .||....|...||:.|..|.:.|:::||:|||::||.|.:|::.|......|.|:||::...:.|
  Rat   174 LVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFGTAFVNSFYQYLF 238

  Fly   178 SRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLA 242
            .||....::.........||.|:|..:.|...: |:...|:..|::.....|..|.:||....|.
  Rat   239 FRFFVAQASVGYAICSVSLVMEWLVGEHRAQAI-ILQHCFFTIGVILLTGFAYKINHWRLLFLLG 302

  Fly   243 SLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKYYRERE--LQ 305
            .:|...::...:::.||.:||:.|.|.::|...|...|:.|::.:..::.:|.....::.:  :.
  Rat   303 GVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNKKTIPLNLLNELQLPGKKAKASIL 367

  Fly   306 DYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLP 370
            |:..|.|   ...:.|......||    |..|.:|||.     .|:..|...:.:.....|..:|
  Rat   368 DFYTNQH---LFKVVLAMGCVWFT----VSYVSLTLSL-----KMKDFGLDIYFIQVVPCITAVP 420

  Fly   371 AGVAILLLQNKIGRKGMACTALFVGGLIT-TATGFMIAHLDPTENALLLAIMVGLGRFGATVSYD 434
            |.:..:||....|||......|   .|:| |....:..   |.|......:|:.||.|....:..
  Rat   421 ARLCCILLLEYFGRKWSLNLTL---SLVTFTCLSLLFV---PEELKSTTILMLVLGEFSMAGTVS 479

  Fly   435 AEIQYAAEIIPTSVRGQAVSNIHVIGLAS--SSLAFYVIYLAQYYKPLPSIFISCLMFFGAGLCL 497
            ....|.||::||.:|...:..:.:...|.  ||||.:    .|....|| ||..||....| ||.
  Rat   480 IFFIYTAELLPTILRSTGLGMVSIAWTAGAISSLAIF----KQTKTQLP-IFFCCLCCILA-LCF 538

  Fly   498 T--LPETLNKKLPETL 511
            :  :|||.|:.|.:::
  Rat   539 SSLVPETGNQPLRDSI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	134/525 (26%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	97/379 (26%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	104/407 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100