DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	153/546 - (28%)
Similarity:	233/546 - (42%)	Gaps:	63/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSVY 66
            |:.:|....|.:|.||.:|..|...:.|....:..|...:..||||.|.......||     |.:
  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLS-----SAW 62

  Fly    67 ENIS-----------ASSCT----------PLLGVVNGTGVVSTNRKCRN----WIFNRESGYES 106
            .|.|           ..||.          ..||:..|..|.....:..|    |.:|::....:
  Rat    63 RNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLST 127

  Fly   107 ITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATG-DFITSFVH 170
            |.||...||.......:..|.||:|.::|:.|.|.|||:.|| .::|..|:...|| .|:..|..
  Rat   128 IVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGR-KNVLFLTMGMQTGFSFLQLFSV 191

  Fly   171 TLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNW 235
            ....|.....:.|:...:.|...::|..|.||...|.....:.:.:||.||.|..|..|.:|.:|
  Rat   192 NFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDW 256

  Fly   236 RRYLWLASLPALGVLIYP--FLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFVKY 298
            |..|...::|  |||...  :.|.||.:||:::.:..:|.:.::|.||||......::||
  Rat   257 RMLLLALTVP--GVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFD----- 314

  Fly   299 YRERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDV-------INRNMEG-LGT 355
              ..||||  |||.:.....::...|.|...: :.:.|:|:.|:..|       ...|:.| :..
  Rat   315 --PSELQD--LNSKKPQSHHIYDLVRTRNIRI-ITIMSIILWLTISVGYFGLSLDTPNLHGDIYV 374

  Fly   356 SPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAI 420
            :.|.|    :.|.:||.|...||...:.|:.....|||:||.:     .:...|.|:|...|...
  Rat   375 NCFLL----AAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSV-----LLFIQLVPSELFYLSTA 430

  Fly   421 MVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFI 485
            :|.:|:||.|.:|.....|.||:.||.||...|..........|.|:.|.:||..|.:.||.|.:
  Rat   431 LVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILM 495

  Fly   486 SCLMFFGAGLCLTLPETLNKKLPETL 511
            ..|....|.|.|..||:....||:|:
  Rat   496 GSLTILTAILTLFFPESFGAPLPDTI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	150/534 (28%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	114/383 (30%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	150/534 (28%)
		MFS	123..510	CDD:119392	119/408 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950