DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and Sv2c

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	681	Identity:	127/681 - (18%)
Similarity:	210/681 - (30%)	Gaps:	268/681 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSVYE 67
            :..::.:|| :||||..:..:.|                      ....||  |:.|..:..|..
  Rat   138 YELIIQECG-HGRFQWALFFVLG----------------------MALMAD--GVEVFVVGFVLP 177

  Fly    68 NISASSCTPLLGVVNGTGVVSTNRKCRNWIFNRESGYESITTELKWVCDKSHHPAVGQSFFFMGS 132
            :.....|.|                      |..||         |:          .|..::|.
  Rat   178 SAETDLCIP----------------------NSGSG---------WL----------GSIVYLGM 201

  Fly   133 VVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFMSGLSTDTMYYLMYILV 197
            :||...:|.|:|:|||..|||:.........|::|||....:|...|.:||.........::...
  Rat   202 MVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYF 266

  Fly   198 FEYLSPKSRTFGLNIILAVFYCFGLMTS--PWAAI----W---------IGNWRRYLWLASLPAL 247
            .|.|:.:.|...|:.:...:...|:..|  .||.|    |         ..:||.::.:.:||.:
  Rat   267 AEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCV 331

  Fly   248 GVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFN--RRHVEESVF-----------DEFVK-- 297
            ..::....:.||.::||...|:|:|.:.||.:...|  .|...|.||           ||.::
  Rat   332 SSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIE 396

  Fly   298 -----YYR------ERELQDYKLNSHEDTFLAMFLTPRLRRFTLTLLVKSVIITLS--------- 342
                 :||      ..||....|     ||:..|..| :|..|:.|.:  |..|||
  Rat   397 SDTGTWYRRCFVRIRTELYGIWL-----TFMRCFNYP-VRENTIKLTI--VWFTLSFGYYGLSVW 453

  Fly   343 ----------------------------------------------------------------- 342

  Rat   454 FPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFK 518

  Fly   343 ----------------CDVINRNMEGLGTSPFKLF-------SFT-------------------- 364
                            |..|:...|.....|:|..       ||.
  Rat   519 SCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIY 583

  Fly   365 ------SIVYLPAGVAILLLQNKIGR----------KGMACTALFVGGLITTATGFMIAHLDPTE 413
                  ::..||..:...||.::|||          .|::|..|:.|    |:...||.
  Rat   584 FVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFG----TSESMMIG------ 638

  Fly   414 NALLLAIMVGLGRFGATVS-YDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLAFYVI-YLAQY 476
               :|.:..||     |:| :::......|:.||..|......::.:..|::.|...:. .|...
  Rat   639 ---MLCLYNGL-----TISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSI 695

  Fly   477 YKPLPSIFISCLMFFGAGLCLTLPETLNKKL 507
            .|.:|.:..|.::..|..:.|.||:|..:.|
  Rat   696 TKAIPILLASTVLVCGGLVGLRLPDTRTQVL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	126/673 (19%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	105/548 (19%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	127/681 (19%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120
		MFS	155..719	CDD:119392	117/654 (18%)
		Pentapeptide_3	507..561	CDD:290309	5/53 (9%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910