DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7333 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	118/527 - (22%)
Similarity:	223/527 - (42%)	Gaps:	23/527 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFSQVLDKCGNYGRFQVMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLSVEGIRSV 65
            |.|:.:|.:.|..||||::.:.:.....:|.:.|...|......|.|.|.......||.:|....
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65

  Fly    66 Y----ENISASSC----TPLLG--VVNGT---GVVSTNRKCRNWIFNRESGYESITTELKWVCDK 117
            :    :.....||    :|..|  ..|||   |...|......|:::..:...:|.||...||..
  Rat    66 WLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSH 130

  Fly   118 SHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFITSFVHTLPWFAFSRFMS 182
            .....:.||.:.:|.::|.::||||:|::||...|::..|..|......::......:...|.:|
  Rat   131 RAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLS 195

  Fly   183 GLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIWIGNWRRYLWLASLPAL 247
            |:|..::......|..|::...:|.: :..::...|..|.......|..:.:||....:.|:|..
  Rat   196 GMSLASIAINCMTLNVEWMPIHTRAY-VGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFF 259

  Fly   248 GVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFD-EFVKYYRERELQDYKLNS 311
            ...||.:...|||:|..:..:.|..:..|::||:.|.:..|.:... |.::...::||   .|:.
  Rat   260 IAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKEL---TLSK 321

  Fly   312 HEDTFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLGTSPFKLFSFTSIVYLPAGVAIL 376
            .:.:.:.:...|.||...|.|.:.....:.:...:..:::|.|.|.:.:......|.|||.....
  Rat   322 GQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCF 386

  Fly   377 LLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLAIMVGLGRFGATVSYDAEIQYAA 441
            |:.|.:||:.....:|.:.|:.....|.:     |..:.::...:..||:.....|::....|..
  Rat   387 LVINSMGRRPAQMASLLLAGICILVNGII-----PKSHTIIRTSLAVLGKGCLASSFNCIFLYTG 446

  Fly   442 EIIPTSVRGQAVSNIHVIGLASSSLAFYVIYLAQYYKPLPSIFISCLMFFGAGLCLTLPETLNKK 506
            |:.||.:|...:.....:....|.::..|...|::|..:|......:....:.:...|||||.:.
  Rat   447 ELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQP 511

  Fly   507 LPETLAD 513
            ||:|:.|
  Rat   512 LPDTVQD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	113/512 (22%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	76/373 (20%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	113/512 (22%)
		MFS	135..505	CDD:119392	77/378 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950