DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7333 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_113772.1	Gene:	Slc22a2 / 29503	RGDID:	61936	Length:	593	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	146/585 - (24%)
Similarity:	238/585 - (40%)	Gaps:	96/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLDKCGNYGRFQ-----VMILLLYGYTNILGSLHYFSQTLITFTPEHWCF--------------H 51
            :|:..|.:..||     ::.||...:|.|     |.....:.|||:|.|:              .
  Rat     7 ILEHIGEFHLFQKQTFFLLALLSGAFTPI-----YVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQ 66

  Fly    52 ADLNGLSVEGIRSVYENISASSC--------TPLLGVVNGTGVVSTNRK------CRN-WIFNRE 101
            |:....:|.|:....|....|.|        ...|..|:....::.:|.      |.: |::|..
  Rat    67 AEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGPCEHGWVYNTP 131

  Fly   102 SGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFIT 166
            .  .||.||...||..|....:.||...:|..:|.::.|||:|:.||...||:..|..|....:.
  Rat   132 G--SSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISGALM 194

  Fly   167 SFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLSPKSRTFGLNIILAVFYCFGLMTSPWAAIW 231
            :......|....||:.||.:...:.:.|||:.|::....|.. :.|...:.:..||:.....|..
  Rat   195 AISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRM-VGICYQIAFTVGLLILAGVAYV 258

  Fly   232 IGNWRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEFV 296
            |.|||...:..:||....|:|.:.|.||.:||:::.|...|:..:|.:||.|.:.|..|
  Rat   259 IPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVS------ 317

  Fly   297 KYYRERELQDYKLNSHED-------TFLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGLG 354
                   ||:  |...||       :.|.:..||::|:.||.|:......::....:..:|...|
  Rat   318 -------LQN--LTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAG 373

  Fly   355 TSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLLA 419
            .:.:..|.::::|..||...|:|..:::||:.....:..|.|....|:.|:     |.:...|..
  Rat   374 DNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFI-----PDDLQWLKI 433

  Fly   420 IMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLA--------FYVIYLAQY 476
            .:..|||.|.|::|:......||:.||.:|...|       |..||:.        |.|..|...
  Rat   434 TIACLGRMGITMAYEMVCLVNAELYPTYIRNLGV-------LVCSSMCDIGGIITPFLVYRLTDI 491

  Fly   477 YKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNESFLYFPCFSRKEKNVRTESV 541
            :...|.:..:.:......|.|.||||..|.||||:.|.|.            ..|..|..|.|::
  Rat   492 WMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAEN------------MQRPRKKERKENL 544

Fly 542 541
Rat 545 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	137/547 (25%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	97/387 (25%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	137/547 (25%)
Slc22a2	NP_113772.1	MFS	125..492	CDD:119392	104/396 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950